node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM9 | CDH1 | ENSP00000419446 | ENSP00000261769 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.690 |
ADAM9 | COL17A1 | ENSP00000419446 | ENSP00000340937 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane | 0.931 |
ADAM9 | ITGA3 | ENSP00000419446 | ENSP00000007722 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration | 0.602 |
ADAM9 | ITGA6 | ENSP00000419446 | ENSP00000386896 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | integrin, alpha 6 | 0.614 |
ADAM9 | ITGAV | ENSP00000419446 | ENSP00000261023 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | integrin, alpha V | 0.732 |
ADAM9 | MAD2L2 | ENSP00000419446 | ENSP00000235310 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | MAD2 mitotic arrest deficient-like 2 (yeast); Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated pho [...] | 0.989 |
ADAM9 | PACSIN3 | ENSP00000419446 | ENSP00000298838 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | 0.713 |
ADAM9 | PRKCD | ENSP00000419446 | ENSP00000331602 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | protein kinase C, delta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates t [...] | 0.588 |
ADAM9 | SH3D19 | ENSP00000419446 | ENSP00000302913 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | SH3 domain containing 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.694 |
ADAM9 | SH3GL2 | ENSP00000419446 | ENSP00000369981 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | SH3-domain GRB2-like 2; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature | 0.736 |
ADAM9 | SH3GLB1 | ENSP00000419446 | ENSP00000418744 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.572 |
ADAM9 | SNX9 | ENSP00000419446 | ENSP00000376024 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | sorting nexin 9; May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate [...] | 0.976 |
ADAM9 | TNF | ENSP00000419446 | ENSP00000398698 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | tumor necrosis factor | 0.895 |
ADAM9 | UBC | ENSP00000419446 | ENSP00000344818 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | ubiquitin C | 0.855 |
CDH1 | ADAM9 | ENSP00000261769 | ENSP00000419446 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP | 0.690 |
CDH1 | DLG1 | ENSP00000261769 | ENSP00000345731 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | discs, large homolog 1 (Drosophila) | 0.936 |
CDH1 | ITGA6 | ENSP00000261769 | ENSP00000386896 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | integrin, alpha 6 | 0.947 |
CDH1 | MAD2L2 | ENSP00000261769 | ENSP00000235310 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | MAD2 mitotic arrest deficient-like 2 (yeast); Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated pho [...] | 0.964 |
CDH1 | TNF | ENSP00000261769 | ENSP00000398698 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | tumor necrosis factor | 0.515 |
CDH1 | UBC | ENSP00000261769 | ENSP00000344818 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | ubiquitin C | 0.999 |