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RCBTB1 RCBTB1 RPGR RPGR RCCD1 RCCD1 HERC3 HERC3 ALS2 ALS2 NEK9 NEK9 HERC6 HERC6 RCBTB2 RCBTB2 ELP2 ELP2 HERC4 HERC4 ELP3 ELP3 RCC1 RCC1 IKBKAP IKBKAP WBSCR16 WBSCR16 DPH3 DPH3 SERGEF SERGEF HERC1 HERC1 DPH1 DPH1 EEF2 EEF2 HERC2 HERC2 HECTD4 HECTD4 DPH2 DPH2 IBTK IBTK EFTUD2 EFTUD2 RCC2 RCC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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NEK9NIMA-related kinase 9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (979 aa)
DPH2DPH2 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity) (489 aa)
ELP3elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration (547 aa)
RCBTB1regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; May be involved in cell cycle regulation by chromatin remodeling (531 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 (4834 aa)
DPH1DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) (443 aa)
ALS2amyotrophic lateral sclerosis 2 (juvenile); May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity) (1657 aa)
HERC3HECT and RLD domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) (1050 aa)
HERC6HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (1022 aa)
SERGEFsecretion regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process (458 aa)
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase (1353 aa)
EEF2eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (858 aa)
WBSCR16Williams-Beuren syndrome chromosome region 16 (464 aa)
RCBTB2regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 (551 aa)
RCC1regulator of chromosome condensation 1; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly (452 aa)
IKBKAPinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (1332 aa)
RCC2regulator of chromosome condensation 2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 (522 aa)
RPGRretinitis pigmentosa GTPase regulator (1152 aa)
RCCD1RCC1 domain containing 1 (376 aa)
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) (1057 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (4861 aa)
EFTUD2elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (972 aa)
ELP2elongator acetyltransferase complex subunit 2 (891 aa)
DPH3DPH3, KTI11 homolog (S. cerevisiae); Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity) (82 aa)
HECTD4HECT domain containing E3 ubiquitin protein ligase 4 (4272 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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