Your Input:
|
||||
TRIM47 | tripartite motif containing 47 (638 aa) | |||
PPP1R12A | protein phosphatase 1, regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity (1030 aa) | |||
DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6; In the process of mRNA degradation, may play a role in mRNA decapping (483 aa) | |||
LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) (385 aa) | |||
DCP1B | DCP1 decapping enzyme homolog B (S. cerevisiae); May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) (617 aa) | |||
NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate (350 aa) | |||
ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 (414 aa) | |||
SKA3 | spindle and kinetochore associated complex subunit 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization (412 aa) | |||
EDC3 | enhancer of mRNA decapping 3 homolog (S. cerevisiae); Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis (508 aa) | |||
CUL1 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] (776 aa) | |||
UBC | ubiquitin C (685 aa) | |||
HSPB9 | heat shock protein, alpha-crystallin-related, B9 (159 aa) | |||
APOA1BP | apolipoprotein A-I binding protein; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) (288 aa) | |||
PGM1 | phosphoglucomutase 1 (580 aa) | |||
RPA2 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage (270 aa) | |||
CDA | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (146 aa) | |||
XRN2 | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription (950 aa) | |||
ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) (342 aa) | |||
PGM2 | phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (612 aa) | |||
PRPS2 | phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis (321 aa) | |||
LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae); Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs (463 aa) | |||
HELZ2 | helicase with zinc finger 2, transcriptional coactivator; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (2649 aa) | |||
NUDT5 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (219 aa) | |||
PRPS1L1 | phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis (318 aa) | |||
YJEFN3 | YjeF N-terminal domain containing 3; May play a role in spermiogenesis and oogenesis (299 aa) | |||
ENSG00000258674 | cDNA FLJ59191, highly similar to NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 (273 aa) |