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TRMT11 TRMT11 RSL1D1 RSL1D1 CEBPZ CEBPZ NOC2L NOC2L KIAA0020 KIAA0020 RPF2 RPF2 NIP7 NIP7 RBM28 RBM28 NOC3L NOC3L GTPBP4 GTPBP4 METTL1 METTL1 EIF6 EIF6 PES1 PES1 MKI67IP MKI67IP MAGEA11 MAGEA11 WDR12 WDR12 WDR74 WDR74 DDX54 DDX54 MRPL15 MRPL15 NSUN4 NSUN4 UBC UBC MTERFD2 MTERFD2 EWSR1 EWSR1 ELAVL1 ELAVL1 MTHFD1L MTHFD1L MTHFD1 MTHFD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RBM28RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes (759 aa)
CEBPZCCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter (1054 aa)
MTERFD2MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation (381 aa)
NIP7nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
WDR12WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
WDR74WD repeat domain 74 (385 aa)
MKI67IPMKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
METTL1methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (276 aa)
NOC2Lnucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter (749 aa)
DDX54DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa)
TRMT11tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) (463 aa)
UBCubiquitin C (685 aa)
PES1pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa)
MAGEA11melanoma antigen family A, 11; Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression (429 aa)
GTPBP4GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) (978 aa)
NOC3Lnucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa)
EIF6eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa)
KIAA0020KIAA0020 (648 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
EWSR1Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (661 aa)
RPF2ribosome production factor 2 homolog (S. cerevisiae) (306 aa)
NSUN4NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis (384 aa)
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa)
RSL1D1ribosomal L1 domain containing 1 (490 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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