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TRIP13 TRIP13 BCL3 BCL3 NISCH NISCH ATP13A2 ATP13A2 LAMP3 LAMP3 SEC24A SEC24A PLIN3 PLIN3 RHEB RHEB UBC UBC RHOBTB3 RHOBTB3 TM9SF2 TM9SF2 RABEPK RABEPK GDI2 GDI2 RAB9A RAB9A VPS33B VPS33B PLEKHM2 PLEKHM2 WIPF1 WIPF1 VPS41 VPS41 VPS33A VPS33A VPS16 VPS16 GDI1 GDI1 WIPF2 WIPF2 MON1A MON1A ENSG00000256861 ENSG00000256861 MON1B MON1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
BCL3B-cell CLL/lymphoma 3; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity) (454 aa)
TRIP13thyroid hormone receptor interactor 13; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] (432 aa)
PLIN3perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (434 aa)
MON1BMON1 homolog B (yeast) (547 aa)
RHEBRas homolog enriched in brain; Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (184 aa)
LAMP3lysosomal-associated membrane protein 3; May play a role in dendritic cell function and in adaptive immunity (416 aa)
VPS33Avacuolar protein sorting 33 homolog A (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity) (596 aa)
MON1AMON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity) (652 aa)
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae); Required for vacuolar assembly and vacuolar traffic (854 aa)
WIPF2WAS/WASL interacting protein family, member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (440 aa)
ATP13A2ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (1180 aa)
VPS33Bvacuolar protein sorting 33 homolog B (yeast); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (617 aa)
NISCHnischarin (1504 aa)
UBCubiquitin C (685 aa)
WIPF1WAS/WASL interacting protein family, member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus (503 aa)
RABEPKRab9 effector protein with kelch motifs (372 aa)
PLEKHM2pleckstrin homology domain containing, family M (with RUN domain) member 2 (1019 aa)
TM9SF2transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter (663 aa)
RHOBTB3Rho-related BTB domain containing 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (611 aa)
GDI2GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (445 aa)
VPS16vacuolar protein sorting 16 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (839 aa)
SEC24ASEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (1093 aa)
GDI1GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (447 aa)
RAB9ARAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (201 aa)
ENSG00000256861Uncharacterized protein (538 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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