node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DRG1 | DRG2 | ENSP00000329715 | ENSP00000225729 | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | 0.875 |
DRG1 | GCN1L1 | ENSP00000329715 | ENSP00000300648 | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 0.570 |
DRG1 | RWDD1 | ENSP00000329715 | ENSP00000420357 | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity) | 0.990 |
DRG1 | UBC | ENSP00000329715 | ENSP00000344818 | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | ubiquitin C | 0.988 |
DRG1 | ZC3H15 | ENSP00000329715 | ENSP00000338788 | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | zinc finger CCCH-type containing 15; Protects DRG1 from proteolytic degradation (By similarity) | 0.999 |
DRG2 | DRG1 | ENSP00000225729 | ENSP00000329715 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | 0.875 |
DRG2 | GCN1L1 | ENSP00000225729 | ENSP00000300648 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 0.966 |
DRG2 | RWDD1 | ENSP00000225729 | ENSP00000420357 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity) | 0.999 |
DRG2 | UBC | ENSP00000225729 | ENSP00000344818 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | ubiquitin C | 0.957 |
DRG2 | ZC3H15 | ENSP00000225729 | ENSP00000338788 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death | zinc finger CCCH-type containing 15; Protects DRG1 from proteolytic degradation (By similarity) | 0.873 |
EEF1A1 | GCN1L1 | ENSP00000330054 | ENSP00000300648 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 0.570 |
EEF1A1 | UBC | ENSP00000330054 | ENSP00000344818 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | ubiquitin C | 0.999 |
EEF1A2 | GCN1L1 | ENSP00000217182 | ENSP00000300648 | eukaryotic translation elongation factor 1 alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 0.474 |
EEF1A2 | IMPACT | ENSP00000217182 | ENSP00000284202 | eukaryotic translation elongation factor 1 alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) | 0.452 |
EEF1A2 | UBC | ENSP00000217182 | ENSP00000344818 | eukaryotic translation elongation factor 1 alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis | ubiquitin C | 0.996 |
ESF1 | NOP2 | ENSP00000202816 | ENSP00000382392 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.736 |
ESF1 | NSUN6 | ENSP00000202816 | ENSP00000366519 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.736 |
ESF1 | RWDD1 | ENSP00000202816 | ENSP00000420357 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity) | 0.630 |
ESF1 | UBC | ENSP00000202816 | ENSP00000344818 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) | ubiquitin C | 0.721 |
GCN1L1 | DRG1 | ENSP00000300648 | ENSP00000329715 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest | 0.570 |