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AURKA | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] (403 aa) | |||
THG1L | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae); Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (298 aa) | |||
APCS | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin (223 aa) | |||
PRPH | peripherin; Class-III neuronal intermediate filament protein (470 aa) | |||
ARPC5L | actin related protein 2/3 complex, subunit 5-like; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity) (153 aa) | |||
FAF2 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (445 aa) | |||
TRMT10A | tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity) (339 aa) | |||
EGFR | epidermal growth factor receptor (1210 aa) | |||
DBN1 | drebrin 1; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively (651 aa) | |||
ICT1 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa) | |||
C17orf61 | chromosome 17 open reading frame 61 (113 aa) | |||
IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial (1012 aa) | |||
GAA | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes (952 aa) | |||
PRKCDBP | protein kinase C, delta binding protein; Seems to have an immune potentiation function (By similarity) (261 aa) | |||
PTBP3 | polypyrimidine tract binding protein 3 (555 aa) | |||
UBC | ubiquitin C (685 aa) | |||
RPL21 | ribosomal protein L21 (160 aa) | |||
RANGAP1 | Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (587 aa) | |||
PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (381 aa) | |||
PPT2 | palmitoyl-protein thioesterase 2 (308 aa) | |||
MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa) | |||
TMEM165 | transmembrane protein 165 (324 aa) | |||
RPL32 | ribosomal protein L32 (135 aa) | |||
CALU | calumenin (323 aa) | |||
EMC1 | ER membrane protein complex subunit 1 (993 aa) | |||
SARS2 | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) (520 aa) |