14 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Your Input:
	CTSZ	cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity (303 aa)
	CTSH	cathepsin H; Important for the overall degradation of proteins in lysosomes (335 aa)
	CTSC	cathepsin C (463 aa)
	CTSL2	cathepsin L2; Cysteine protease. May have an important role in corneal physiology (334 aa)
	CTSK	cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (329 aa)
	CTSF	cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis (484 aa)
	CTSW	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity (376 aa)
	CTSB	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis (339 aa)
	CTSL1	cathepsin L1; Important for the overall degradation of proteins in lysosomes (333 aa)
	HLA-DRB1	major histocompatibility complex, class II, DR beta 1 (266 aa)
	CTSS	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N (331 aa)
	HLA-DRA	major histocompatibility complex, class II, DR alpha (254 aa)
	GABRR2	gamma-aminobutyric acid (GABA) A receptor, rho 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (490 aa)
	CST7	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system (145 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CST7	CTSB	ENSP00000420384	ENSP00000342070	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	0.734
CST7	CTSC	ENSP00000420384	ENSP00000227266	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin C	0.628
CST7	CTSL1	ENSP00000420384	ENSP00000345344	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin L1; Important for the overall degradation of proteins in lysosomes	0.665
CST7	CTSS	ENSP00000420384	ENSP00000357981	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N	0.475
CTSB	CST7	ENSP00000342070	ENSP00000420384	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.734
CTSB	CTSL1	ENSP00000342070	ENSP00000345344	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	cathepsin L1; Important for the overall degradation of proteins in lysosomes	0.700
CTSB	CTSL2	ENSP00000342070	ENSP00000259470	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	cathepsin L2; Cysteine protease. May have an important role in corneal physiology	0.685
CTSC	CST7	ENSP00000227266	ENSP00000420384	cathepsin C	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.628
CTSC	CTSL1	ENSP00000227266	ENSP00000345344	cathepsin C	cathepsin L1; Important for the overall degradation of proteins in lysosomes	0.672
CTSF	CTSS	ENSP00000310832	ENSP00000357981	cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N	0.916
CTSF	HLA-DRB1	ENSP00000310832	ENSP00000353099	cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	major histocompatibility complex, class II, DR beta 1	0.900
CTSL1	CST7	ENSP00000345344	ENSP00000420384	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.665
CTSL1	CTSB	ENSP00000345344	ENSP00000342070	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	0.700
CTSL1	CTSC	ENSP00000345344	ENSP00000227266	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cathepsin C	0.672
CTSL1	CTSS	ENSP00000345344	ENSP00000357981	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N	0.905
CTSL1	HLA-DRB1	ENSP00000345344	ENSP00000353099	cathepsin L1; Important for the overall degradation of proteins in lysosomes	major histocompatibility complex, class II, DR beta 1	0.901
CTSL2	CTSB	ENSP00000259470	ENSP00000342070	cathepsin L2; Cysteine protease. May have an important role in corneal physiology	cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis	0.685
CTSL2	CTSS	ENSP00000259470	ENSP00000357981	cathepsin L2; Cysteine protease. May have an important role in corneal physiology	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N	0.905
CTSL2	HLA-DRB1	ENSP00000259470	ENSP00000353099	cathepsin L2; Cysteine protease. May have an important role in corneal physiology	major histocompatibility complex, class II, DR beta 1	0.900
CTSS	CST7	ENSP00000357981	ENSP00000420384	cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.475

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