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DERL2 DERL2 DERL1 DERL1 ZFAND2B ZFAND2B FAF2 FAF2 CALU CALU FLOT1 FLOT1 ELOVL3 ELOVL3 UBE2G2 UBE2G2 ELOVL6 ELOVL6 TSSK1B TSSK1B EMC3 EMC3 EMC4 EMC4 EMC2 EMC2 TRIB2 TRIB2 MMGT1 MMGT1 EMC1 EMC1 EMC10 EMC10 DHDH DHDH EMC9 EMC9 EMC8 EMC8 EMC7 EMC7 ILF3 ILF3 TSSK3 TSSK3 STK11 STK11 ILF2 ILF2 CENPH CENPH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TRIB2tribbles homolog 2 (Drosophila); Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity) (343 aa)
DERL2derlin 2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation (239 aa)
EMC9ER membrane protein complex subunit 9 (208 aa)
EMC2ER membrane protein complex subunit 2 (297 aa)
DHDHdihydrodiol dehydrogenase (dimeric) (334 aa)
EMC3ER membrane protein complex subunit 3 (261 aa)
EMC8ER membrane protein complex subunit 8 (210 aa)
EMC7ER membrane protein complex subunit 7 (242 aa)
DERL1derlin 1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class [...] (251 aa)
FAF2Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (445 aa)
EMC4ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa)
CENPHcentromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (247 aa)
ZFAND2Bzinc finger, AN1-type domain 2B (257 aa)
ELOVL6ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa)
MMGT1membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa)
STK11serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] (433 aa)
EMC10ER membrane protein complex subunit 10 (262 aa)
UBE2G2ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa)
ILF2interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus (390 aa)
ELOVL3ELOVL fatty acid elongase 3; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Highest activity toward C18 acyl-CoAs, especially C18-0 acyl-CoAs (270 aa)
TSSK3testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function (268 aa)
FLOT1flotillin 1 (427 aa)
TSSK1Btestis-specific serine kinase 1B; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates ’Ser-288’ of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (367 aa)
ILF3interleukin enhancer binding factor 3, 90kDa (898 aa)
CALUcalumenin (323 aa)
EMC1ER membrane protein complex subunit 1 (993 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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