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TRIB2 | tribbles homolog 2 (Drosophila); Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity) (343 aa) | |||
DERL2 | derlin 2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation (239 aa) | |||
EMC9 | ER membrane protein complex subunit 9 (208 aa) | |||
EMC2 | ER membrane protein complex subunit 2 (297 aa) | |||
DHDH | dihydrodiol dehydrogenase (dimeric) (334 aa) | |||
EMC3 | ER membrane protein complex subunit 3 (261 aa) | |||
EMC8 | ER membrane protein complex subunit 8 (210 aa) | |||
EMC7 | ER membrane protein complex subunit 7 (242 aa) | |||
DERL1 | derlin 1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class [...] (251 aa) | |||
FAF2 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (445 aa) | |||
EMC4 | ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa) | |||
CENPH | centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (247 aa) | |||
ZFAND2B | zinc finger, AN1-type domain 2B (257 aa) | |||
ELOVL6 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa) | |||
MMGT1 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa) | |||
STK11 | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] (433 aa) | |||
EMC10 | ER membrane protein complex subunit 10 (262 aa) | |||
UBE2G2 | ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa) | |||
ILF2 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus (390 aa) | |||
ELOVL3 | ELOVL fatty acid elongase 3; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Highest activity toward C18 acyl-CoAs, especially C18-0 acyl-CoAs (270 aa) | |||
TSSK3 | testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function (268 aa) | |||
FLOT1 | flotillin 1 (427 aa) | |||
TSSK1B | testis-specific serine kinase 1B; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates ’Ser-288’ of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (367 aa) | |||
ILF3 | interleukin enhancer binding factor 3, 90kDa (898 aa) | |||
CALU | calumenin (323 aa) | |||
EMC1 | ER membrane protein complex subunit 1 (993 aa) |