Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | EMC9 | ER membrane protein complex subunit 9 (208 aa) | ||
 | EMC2 | ER membrane protein complex subunit 2 (297 aa) | ||
 | DHDH | dihydrodiol dehydrogenase (dimeric) (334 aa) | ||
 | SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) (476 aa) | ||
 | EMC3 | ER membrane protein complex subunit 3 (261 aa) | ||
 | EMC6 | ER membrane protein complex subunit 6 (110 aa) | ||
 | EMC8 | ER membrane protein complex subunit 8 (210 aa) | ||
 | EMC7 | ER membrane protein complex subunit 7 (242 aa) | ||
 | EMC4 | ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa) | ||
 | CENPH | centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (247 aa) | ||
 | SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa) | ||
 | UBB | ubiquitin B (229 aa) | ||
 | ELOVL6 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa) | ||
 | MMGT1 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa) | ||
 | EMC10 | ER membrane protein complex subunit 10 (262 aa) | ||
 | UBL4B | ubiquitin-like 4B (174 aa) | ||
 | UBE2G2 | ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa) | ||
 | OAS2 | 2’-5’-oligoadenylate synthetase 2, 69/71kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2’-5’-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the [...] (719 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | ILF2 | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus (390 aa) | ||
 | UBL4A | ubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa) | ||
 | ELOVL3 | ELOVL fatty acid elongase 3; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Highest activity toward C18 acyl-CoAs, especially C18-0 acyl-CoAs (270 aa) | ||
 | ILF3 | interleukin enhancer binding factor 3, 90kDa (898 aa) | ||
 | CALU | calumenin (323 aa) | ||
 | EMC1 | ER membrane protein complex subunit 1 (993 aa) | ||
 | UBBP4 | ubiquitin B pseudogene 4 (229 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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