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HYAL4 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (481 aa) | |||
FLRT1 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling (674 aa) | |||
LTK | leukocyte receptor tyrosine kinase; Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (864 aa) | |||
HYAL1 | hyaluronoglucosaminidase 1 (435 aa) | |||
SHANK1 | SH3 and multiple ankyrin repeat domains 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction (2161 aa) | |||
MST1R | macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effect [...] (1400 aa) | |||
USH2A | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision (5202 aa) | |||
MET | met proto-oncogene (hepatocyte growth factor receptor); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 [...] (1408 aa) | |||
IGSF9B | immunoglobulin superfamily, member 9B (1349 aa) | |||
FLRT2 | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling (660 aa) | |||
FLRT3 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling (649 aa) | |||
SHANK2 | SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (1850 aa) | |||
PAPLN | papilin, proteoglycan-like sulfated glycoprotein (1251 aa) | |||
SPAM1 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (511 aa) | |||
HYAL2 | hyaluronoglucosaminidase 2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (473 aa) | |||
KIRREL | kin of IRRE like (Drosophila); Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity) (757 aa) | |||
INSRR | insulin receptor-related receptor; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB (1297 aa) | |||
LRIT1 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction (623 aa) | |||
LRIT3 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (634 aa) | |||
ALK | anaplastic lymphoma receptor tyrosine kinase; Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 [...] (1620 aa) | |||
TENM3 | teneurin transmembrane protein 3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By sim [...] (2699 aa) | |||
SDK1 | sidekick cell adhesion molecule 1; Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV- associated nephropathy (2213 aa) | |||
LPHN3 | latrophilin 3 (1469 aa) | |||
TENM2 | teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa) | |||
KIRREL3 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) (778 aa) | |||
SHANK3 | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (1747 aa) |