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DDX20 DDX20 QTRTD1 QTRTD1 QTRT1 QTRT1 TARBP1 TARBP1 RPL10A RPL10A TPX2 TPX2 SNX8 SNX8 EIF4A1 EIF4A1 TRMT1 TRMT1 UBC UBC THUMPD2 THUMPD2 EIF4A3 EIF4A3 EIF4A2 EIF4A2 DDX17 DDX17 MRPL1 MRPL1 DDX27 DDX27 GPR149 GPR149 DDX39B DDX39B DDX10 DDX10 TDRD12 TDRD12 KCTD19 KCTD19 MRM1 MRM1 DDX21 DDX21 RNMTL1 RNMTL1 DDX50 DDX50 DDX59 DDX59
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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TARBP1TAR (HIV-1) RNA binding protein 1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA (1621 aa)
SNX8sorting nexin 8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (465 aa)
MRM1mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S) (By similarity) (353 aa)
QTRT1queuine tRNA-ribosyltransferase 1; Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) (403 aa)
EIF4A3eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] (411 aa)
QTRTD1queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) (415 aa)
EIF4A1eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (406 aa)
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis); Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at ’Thr-288’ and protects this residue against dephosphorylation (747 aa)
KCTD19potassium channel tetramerisation domain containing 19 (926 aa)
RNMTL1RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) (420 aa)
DDX10DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase (875 aa)
MRPL1mitochondrial ribosomal protein L1 (325 aa)
EIF4A2eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (407 aa)
DDX59DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 (619 aa)
UBCubiquitin C (685 aa)
DDX21DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing (783 aa)
TRMT1tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (659 aa)
DDX20DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs (824 aa)
DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (796 aa)
DDX50DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 (737 aa)
RPL10Aribosomal protein L10a (217 aa)
GPR149G protein-coupled receptor 149; Orphan receptor (731 aa)
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (428 aa)
DDX17DEAD (Asp-Glu-Ala-Asp) box helicase 17; RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation (731 aa)
TDRD12tudor domain containing 12 (395 aa)
THUMPD2THUMP domain containing 2 (503 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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