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STRINGSTRING
DHX40 DHX40 DHX33 DHX33 DQX1 DQX1 DHX32 DHX32 DHX35 DHX35 YTHDC2 YTHDC2 DHX15 DHX15 DHX16 DHX16 RRP7A RRP7A DHX34 DHX34 DHX37 DHX37 DHX38 DHX38 MRPS5 MRPS5 DHX29 DHX29 DHX8 DHX8 DHX9 DHX9 UBA52 UBA52 PCNA PCNA DHX30 DHX30 UBE2A UBE2A RNF20 RNF20 DHX36 DHX36 TDRD9 TDRD9 RNF40 RNF40 USP17L23 USP17L23 DHX57 DHX57
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
YTHDC2YTH domain containing 2 (1430 aa)
DHX33DEAH (Asp-Glu-Ala-His) box polypeptide 33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization (707 aa)
DHX40DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity) (779 aa)
DHX29DEAH (Asp-Glu-Ala-His) box polypeptide 29; ATP-binding RNA helicase involved in translation initiation. Required for efficient initiation on mammalian mRNAs with structured 5’-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity (1369 aa)
DHX35DEAH (Asp-Glu-Ala-His) box polypeptide 35; May be involved in pre-mRNA splicing (703 aa)
DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (1220 aa)
DHX38DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing (1227 aa)
MRPS5mitochondrial ribosomal protein S5 (430 aa)
DHX32DEAH (Asp-Glu-Ala-His) box polypeptide 32 (743 aa)
DHX57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57; Probable ATP-binding RNA helicase (1386 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
RRP7Aribosomal RNA processing 7 homolog A (S. cerevisiae) (280 aa)
RNF40ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...] (1001 aa)
DHX34DEAH (Asp-Glu-Ala-His) box polypeptide 34; Probable ATP-binding RNA helicase (1143 aa)
DHX15DEAH (Asp-Glu-Ala-His) box polypeptide 15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (By similarity) (795 aa)
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 9; Unwinds double-stranded DNA and RNA in a 3’ to 5’ direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene expression (1270 aa)
UBE2Aubiquitin-conjugating enzyme E2A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Require [...] (152 aa)
DHX16DEAH (Asp-Glu-Ala-His) box polypeptide 16 (1041 aa)
PCNAproliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] (261 aa)
RNF20ring finger protein 20, E3 ubiquitin protein ligase (975 aa)
DQX1DEAQ box RNA-dependent ATPase 1 (717 aa)
TDRD9tudor domain containing 9; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity) (1382 aa)
UBA52ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa)
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 30; Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (1194 aa)
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36; Plays a role in degradation and deadenylation of mRNAs containing in their 3’-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis (1008 aa)
USP17L23ubiquitin specific peptidase 17-like family member 23 (183 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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