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ITCH ITCH CYB5R4 CYB5R4 WWP2 WWP2 CACNA1C CACNA1C TC2N TC2N MRPL15 MRPL15 TRIP12 TRIP12 SV2B SV2B SLC25A17 SLC25A17 EXOC8 EXOC8 SYT1 SYT1 PAG1 PAG1 EXOC1 EXOC1 EXOC2 EXOC2 SLC2A3 SLC2A3 HERC1 HERC1 HACE1 HACE1 SYNJ1 SYNJ1 FIG4 FIG4 HERC3 HERC3 SLC16A6 SLC16A6 RPL27A RPL27A KIAA0317 KIAA0317 HERC4 HERC4 MFSD1 MFSD1 MCTP1 MCTP1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter (496 aa)
PAG1phosphoprotein associated with glycosphingolipid microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling (432 aa)
FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (907 aa)
EXOC2exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (924 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
SYT1synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (909 aa)
HERC3HECT and RLD domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity) (1050 aa)
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit (2186 aa)
TRIP12thyroid hormone receptor interactor 12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located [...] (1992 aa)
SLC16A6solute carrier family 16, member 6 (monocarboxylic acid transporter 7); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (523 aa)
EXOC1exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (894 aa)
SV2Bsynaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) (683 aa)
TC2Ntandem C2 domains, nuclear (490 aa)
RPL27Aribosomal protein L27a (148 aa)
WWP2WW domain containing E3 ubiquitin protein ligase 2 (870 aa)
KIAA0317KIAA0317 (823 aa)
EXOC8exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (725 aa)
CYB5R4cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin (521 aa)
ITCHitchy E3 ubiquitin protein ligase (862 aa)
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) (1057 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (4861 aa)
SLC25A17solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] (307 aa)
MFSD1major facilitator superfamily domain containing 1 (514 aa)
SYNJ1synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis (1612 aa)
MCTP1multiple C2 domains, transmembrane 1 (999 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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