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EVX1 EVX1 EVX2 EVX2 IGSF11 IGSF11 E2F1 E2F1 SLAMF7 SLAMF7 LRIT1 LRIT1 LRIT3 LRIT3 CCNE2 CCNE2 CCNE1 CCNE1 DCLK1 DCLK1 INADL INADL LYZL2 LYZL2 IGSF9B IGSF9B GIF GIF EYS EYS TCN1 TCN1 DLG5 DLG5 TAPBPL TAPBPL CASK CASK NEURL1B NEURL1B PDZD2 PDZD2 LYZL1 LYZL1 NID1 NID1 BCAM BCAM DLL1 DLL1 NEURL NEURL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DCLK1doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (729 aa)
GIFgastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (417 aa)
TCN1transcobalamin I (vitamin B12 binding protein, R binder family); Vitamin B12-binding protein. Transports cobalamin into cells (433 aa)
CCNE1cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa)
NID1nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions (1247 aa)
TAPBPLTAP binding protein-like (468 aa)
BCAMbasal cell adhesion molecule (Lutheran blood group); Laminin alpha-5 receptor. May mediate intracellular signaling (628 aa)
PDZD2PDZ domain containing 2 (2839 aa)
CCNE2cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase (404 aa)
EVX2even-skipped homeobox 2 (476 aa)
IGSF9Bimmunoglobulin superfamily, member 9B (1349 aa)
E2F1E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis (437 aa)
DLL1delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (723 aa)
SLAMF7SLAM family member 7; Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion (335 aa)
NEURLneuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity) (574 aa)
NEURL1Bneuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands (555 aa)
INADLInaD-like (Drosophila) (1801 aa)
LRIT1leucine-rich repeat, immunoglobulin-like and transmembrane domains 1; Possible role in phototransduction (623 aa)
DLG5discs, large homolog 5 (Drosophila) (1919 aa)
LYZL2lysozyme-like 2 (194 aa)
LYZL1lysozyme-like 1 (194 aa)
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
LRIT3leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (634 aa)
IGSF11immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (431 aa)
EVX1even-skipped homeobox 1; May play a role in the specification of neuronal cell types (407 aa)
EYSeyes shut homolog (Drosophila) (3144 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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