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RPS12 RPS12 RPS20 RPS20 RPL13 RPL13 RNPS1 RNPS1 RPS11 RPS11 RPL21 RPL21 RPL15 RPL15 RPL29 RPL29 RPL9 RPL9 RPL6 RPL6 RPS8 RPS8 RPS5 RPS5 RPL13A RPL13A RPL38 RPL38 RPL26L1 RPL26L1 RPS14 RPS14 UPF1 UPF1 MAGOH MAGOH RPS15A RPS15A RPS4X RPS4X RPL31 RPL31 UPF2 UPF2 RPL28 RPL28 RPL36 RPL36 RPL3 RPL3 SMG7 SMG7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPS5ribosomal protein S5 (204 aa)
RPL6ribosomal protein L6; Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (288 aa)
RPS12ribosomal protein S12 (132 aa)
RPL36ribosomal protein L36 (105 aa)
UPF1UPF1 regulator of nonsense transcripts homolog (yeast); RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (loc [...] (1118 aa)
RPL26L1ribosomal protein L26-like 1 (145 aa)
RPS11ribosomal protein S11 (158 aa)
RPL29ribosomal protein L29 (159 aa)
RNPS1RNA binding protein S1, serine-rich domain (305 aa)
RPL13ribosomal protein L13 (211 aa)
RPL15ribosomal protein L15 (204 aa)
RPL38ribosomal protein L38 (70 aa)
RPS14ribosomal protein S14 (151 aa)
RPS15Aribosomal protein S15a (130 aa)
RPL3ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes (403 aa)
RPL9ribosomal protein L9 (192 aa)
RPL21ribosomal protein L21 (160 aa)
UPF2UPF2 regulator of nonsense transcripts homolog (yeast) (1272 aa)
MAGOHmago-nashi homolog, proliferation-associated (Drosophila); Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mR [...] (146 aa)
RPS4Xribosomal protein S4, X-linked (263 aa)
RPL13Aribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses [...] (203 aa)
RPS8ribosomal protein S8 (208 aa)
RPL31ribosomal protein L31 (128 aa)
RPL28ribosomal protein L28 (169 aa)
SMG7smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (1178 aa)
RPS20ribosomal protein S20 (142 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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