node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC5L | CDKN2A | ENSP00000360532 | ENSP00000394932 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.707 |
CDC5L | SNW1 | ENSP00000360532 | ENSP00000261531 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.991 |
CDC5L | SUMO2 | ENSP00000360532 | ENSP00000405965 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.508 |
CDC5L | UBC | ENSP00000360532 | ENSP00000344818 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | ubiquitin C | 0.740 |
CDKN2A | CDC5L | ENSP00000394932 | ENSP00000360532 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.707 |
CDKN2A | CDKN2AIP | ENSP00000394932 | ENSP00000427108 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | 0.985 |
CDKN2A | MDM2 | ENSP00000394932 | ENSP00000417281 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.999 |
CDKN2A | SUMO2 | ENSP00000394932 | ENSP00000405965 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.659 |
CDKN2A | UBC | ENSP00000394932 | ENSP00000344818 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | ubiquitin C | 0.998 |
CDKN2AIP | CDKN2A | ENSP00000427108 | ENSP00000394932 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.985 |
CDKN2AIP | EPHX1 | ENSP00000427108 | ENSP00000272167 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | epoxide hydrolase 1, microsomal (xenobiotic) | 0.644 |
CDKN2AIP | GGH | ENSP00000427108 | ENSP00000260118 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates | 0.644 |
CDKN2AIP | MDM2 | ENSP00000427108 | ENSP00000417281 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.844 |
CDKN2AIP | UBC | ENSP00000427108 | ENSP00000344818 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | ubiquitin C | 0.771 |
CDKN2AIP | XRN2 | ENSP00000427108 | ENSP00000366396 | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription | 0.481 |
EPHX1 | CDKN2AIP | ENSP00000272167 | ENSP00000427108 | epoxide hydrolase 1, microsomal (xenobiotic) | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | 0.644 |
EPHX1 | UBC | ENSP00000272167 | ENSP00000344818 | epoxide hydrolase 1, microsomal (xenobiotic) | ubiquitin C | 0.817 |
GGH | CDKN2AIP | ENSP00000260118 | ENSP00000427108 | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates | CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways | 0.644 |
GGH | UBC | ENSP00000260118 | ENSP00000344818 | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates | ubiquitin C | 0.721 |
MDM2 | CDKN2A | ENSP00000417281 | ENSP00000394932 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.999 |