node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APBB2 | APLP2 | ENSP00000427211 | ENSP00000263574 | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.893 |
APBB2 | APP | ENSP00000427211 | ENSP00000284981 | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor protein | 0.941 |
APBB2 | EGFR | ENSP00000427211 | ENSP00000275493 | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | epidermal growth factor receptor | 0.574 |
APBB2 | UBC | ENSP00000427211 | ENSP00000344818 | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | ubiquitin C | 0.620 |
APLP2 | APBB2 | ENSP00000263574 | ENSP00000427211 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | 0.893 |
APLP2 | APP | ENSP00000263574 | ENSP00000284981 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta (A4) precursor protein | 0.595 |
APLP2 | UBC | ENSP00000263574 | ENSP00000344818 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | ubiquitin C | 0.966 |
APP | APBB2 | ENSP00000284981 | ENSP00000427211 | amyloid beta (A4) precursor protein | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | 0.941 |
APP | APLP2 | ENSP00000284981 | ENSP00000263574 | amyloid beta (A4) precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.595 |
APP | EGFR | ENSP00000284981 | ENSP00000275493 | amyloid beta (A4) precursor protein | epidermal growth factor receptor | 0.662 |
APP | UBC | ENSP00000284981 | ENSP00000344818 | amyloid beta (A4) precursor protein | ubiquitin C | 0.991 |
EGFR | APBB2 | ENSP00000275493 | ENSP00000427211 | epidermal growth factor receptor | amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein | 0.574 |
EGFR | APP | ENSP00000275493 | ENSP00000284981 | epidermal growth factor receptor | amyloid beta (A4) precursor protein | 0.662 |
EGFR | HTT | ENSP00000275493 | ENSP00000347184 | epidermal growth factor receptor | huntingtin; May play a role in microtubule-mediated transport or vesicle function | 0.602 |
EGFR | SMAD4 | ENSP00000275493 | ENSP00000341551 | epidermal growth factor receptor | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.602 |
EGFR | SMURF1 | ENSP00000275493 | ENSP00000354621 | epidermal growth factor receptor | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.830 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
HTT | EGFR | ENSP00000347184 | ENSP00000275493 | huntingtin; May play a role in microtubule-mediated transport or vesicle function | epidermal growth factor receptor | 0.602 |
HTT | UBC | ENSP00000347184 | ENSP00000344818 | huntingtin; May play a role in microtubule-mediated transport or vesicle function | ubiquitin C | 0.999 |
SMAD4 | EGFR | ENSP00000341551 | ENSP00000275493 | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | epidermal growth factor receptor | 0.602 |