8 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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Your Input:
	APLP2	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) (763 aa)
	EGFR	epidermal growth factor receptor (1210 aa)
	APP	amyloid beta (A4) precursor protein (770 aa)
	SMAD4	SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] (552 aa)
	UBC	ubiquitin C (685 aa)
	HTT	huntingtin; May play a role in microtubule-mediated transport or vesicle function (3142 aa)
	SMURF1	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (757 aa)
	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein (759 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB2	APLP2	ENSP00000427211	ENSP00000263574	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	0.893
APBB2	APP	ENSP00000427211	ENSP00000284981	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	amyloid beta (A4) precursor protein	0.941
APBB2	EGFR	ENSP00000427211	ENSP00000275493	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	epidermal growth factor receptor	0.574
APBB2	UBC	ENSP00000427211	ENSP00000344818	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	ubiquitin C	0.620
APLP2	APBB2	ENSP00000263574	ENSP00000427211	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	0.893
APLP2	APP	ENSP00000263574	ENSP00000284981	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	amyloid beta (A4) precursor protein	0.595
APLP2	UBC	ENSP00000263574	ENSP00000344818	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	ubiquitin C	0.966
APP	APBB2	ENSP00000284981	ENSP00000427211	amyloid beta (A4) precursor protein	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	0.941
APP	APLP2	ENSP00000284981	ENSP00000263574	amyloid beta (A4) precursor protein	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	0.595
APP	EGFR	ENSP00000284981	ENSP00000275493	amyloid beta (A4) precursor protein	epidermal growth factor receptor	0.662
APP	UBC	ENSP00000284981	ENSP00000344818	amyloid beta (A4) precursor protein	ubiquitin C	0.991
EGFR	APBB2	ENSP00000275493	ENSP00000427211	epidermal growth factor receptor	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein	0.574
EGFR	APP	ENSP00000275493	ENSP00000284981	epidermal growth factor receptor	amyloid beta (A4) precursor protein	0.662
EGFR	HTT	ENSP00000275493	ENSP00000347184	epidermal growth factor receptor	huntingtin; May play a role in microtubule-mediated transport or vesicle function	0.602
EGFR	SMAD4	ENSP00000275493	ENSP00000341551	epidermal growth factor receptor	SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...]	0.602
EGFR	SMURF1	ENSP00000275493	ENSP00000354621	epidermal growth factor receptor	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA	0.830
EGFR	UBC	ENSP00000275493	ENSP00000344818	epidermal growth factor receptor	ubiquitin C	0.999
HTT	EGFR	ENSP00000347184	ENSP00000275493	huntingtin; May play a role in microtubule-mediated transport or vesicle function	epidermal growth factor receptor	0.602
HTT	UBC	ENSP00000347184	ENSP00000344818	huntingtin; May play a role in microtubule-mediated transport or vesicle function	ubiquitin C	0.999
SMAD4	EGFR	ENSP00000341551	ENSP00000275493	SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...]	epidermal growth factor receptor	0.602

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