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STRINGSTRING
RPS16 RPS16 RPL18 RPL18 RPS23 RPS23 RPS7 RPS7 RPL30 RPL30 RPL5 RPL5 UBC UBC RPL7 RPL7 RPN2 RPN2 RPL34 RPL34 RPL39 RPL39 RPL26 RPL26 SEC61G SEC61G SRP14 SRP14 RPL24 RPL24 RPL19 RPL19 TRAM1 TRAM1 DDOST DDOST RPS3A RPS3A RPS3 RPS3 RPL35 RPL35 RPS29 RPS29 RPL12 RPL12 SPCS3 SPCS3 CDX2 CDX2 ISL1 ISL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPL19ribosomal protein L19 (196 aa)
ISL1ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa)
RPN2ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (631 aa)
RPS16ribosomal protein S16 (146 aa)
RPL35ribosomal protein L35 (123 aa)
TRAM1translocation associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (374 aa)
SRP14signal recognition particle 14kDa (homologous Alu RNA binding protein); Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa)
RPL30ribosomal protein L30 (115 aa)
RPL26ribosomal protein L26 (145 aa)
RPS23ribosomal protein S23 (143 aa)
RPS7ribosomal protein S7; Required for rRNA maturation (194 aa)
RPL7ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (248 aa)
SEC61GSec61 gamma subunit; Necessary for protein translocation in the endoplasmic reticulum (By similarity) (68 aa)
UBCubiquitin C (685 aa)
RPS3Aribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) (264 aa)
RPL12ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) (165 aa)
RPL39ribosomal protein L39 (51 aa)
RPL5ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa)
DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (456 aa)
CDX2caudal type homeobox 2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine (313 aa)
RPL24ribosomal protein L24 (157 aa)
RPL34ribosomal protein L34 (117 aa)
RPS29ribosomal protein S29 (67 aa)
SPCS3signal peptidase complex subunit 3 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (180 aa)
RPS3ribosomal protein S3 (243 aa)
RPL18ribosomal protein L18 (188 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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