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PAX6 PAX6 GATA4 GATA4 RPLP2 RPLP2 RPS27 RPS27 RPL35 RPL35 SPCS3 SPCS3 RPL26 RPL26 RPL41 RPL41 RPL4 RPL4 RPL30 RPL30 SSR3 SSR3 RPN2 RPN2 RPL37 RPL37 RPS16 RPS16 RPS23 RPS23 RPS21 RPS21 RPS2 RPS2 RPL18 RPL18 RPS29 RPS29 RPL17 RPL17 RPL23 RPL23 RPS3A RPS3A RPS28 RPS28 RPL8 RPL8 UBC UBC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPN2ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (631 aa)
RPS16ribosomal protein S16 (146 aa)
RPL35ribosomal protein L35 (123 aa)
RPL8ribosomal protein L8 (257 aa)
SSR3signal sequence receptor, gamma (translocon-associated protein gamma); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins (185 aa)
RPL37ribosomal protein L37; Binds to the 23S rRNA (By similarity) (97 aa)
RPL30ribosomal protein L30 (115 aa)
RPL26ribosomal protein L26 (145 aa)
RPS23ribosomal protein S23 (143 aa)
RPL4ribosomal protein L4 (427 aa)
RPLP2ribosomal protein, large, P2; Plays an important role in the elongation step of protein synthesis (115 aa)
GATA4GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (442 aa)
RPS2ribosomal protein S2 (293 aa)
UBCubiquitin C (685 aa)
RPS21ribosomal protein S21 (83 aa)
RPS3Aribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) (264 aa)
RPS27ribosomal protein S27 (84 aa)
PAX6paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes (436 aa)
RPL23ribosomal protein L23 (140 aa)
RPS29ribosomal protein S29 (67 aa)
RPL41ribosomal protein L41 (25 aa)
SPCS3signal peptidase complex subunit 3 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (180 aa)
RPL18ribosomal protein L18 (188 aa)
RPL17ribosomal protein L17 (184 aa)
RPS28ribosomal protein S28 (69 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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