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FAM13B | family with sequence similarity 13, member B (915 aa) | |||
GMIP | GEM interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA (970 aa) | |||
RHOV | ras homolog family member V; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity) (236 aa) | |||
RHOQ | ras homolog family member Q; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia (205 aa) | |||
DEPDC7 | DEP domain containing 7 (511 aa) | |||
RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (192 aa) | |||
ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) (776 aa) | |||
FAM13A | family with sequence similarity 13, member A (1023 aa) | |||
DEPDC1B | DEP domain containing 1B (529 aa) | |||
FGD2 | FYVE, RhoGEF and PH domain containing 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity) (655 aa) | |||
ARHGAP18 | Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (663 aa) | |||
TIAM1 | T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA (1591 aa) | |||
ARHGAP17 | Rho GTPase activating protein 17 (881 aa) | |||
RHOD | ras homolog family member D; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton (By similarity) (210 aa) | |||
ARHGAP32 | Rho GTPase activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity) (2087 aa) | |||
ARHGAP28 | Rho GTPase activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (570 aa) | |||
TRIP10 | thyroid hormone receptor interactor 10 (545 aa) | |||
STARD13 | StAR-related lipid transfer (START) domain containing 13 (1113 aa) | |||
ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell [...] (1173 aa) | |||
ARHGAP30 | Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42 (1101 aa) | |||
INPP5B | inositol polyphosphate-5-phosphatase, 75kDa (913 aa) | |||
ARHGAP39 | Rho GTPase activating protein 39 (1114 aa) | |||
ARHGAP44 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 (818 aa) | |||
ARHGAP25 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (646 aa) | |||
RHOA | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa) | |||
RHOBTB2 | Rho-related BTB domain containing 2 (749 aa) |