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ACR | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa) | |||
GZMK | granzyme K (granzyme 3; tryptase II) (264 aa) | |||
CMA1 | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion (247 aa) | |||
F12 | coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa) | |||
HPN | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL (417 aa) | |||
ELANE | elastase, neutrophil expressed; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (267 aa) | |||
GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after ’Lys-31’ and destroys its oxidative repair activity. Involved in apoptosis (262 aa) | |||
ST14 | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (855 aa) | |||
CELA3A | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | |||
PRSS37 | protease, serine, 37 (235 aa) | |||
KLK10 | kallikrein-related peptidase 10; Has a tumor-suppressor role for NES1 in breast and prostate cancer (276 aa) | |||
PRSS8 | protease, serine, 8; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) (343 aa) | |||
C1S | complement component 1, s subcomponent (688 aa) | |||
TMPRSS9 | transmembrane protease, serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala- Pro-Ala-AMC are not significantly hydrolyzed (1059 aa) | |||
TMPRSS11B | transmembrane protease, serine 11B; Probable serine protease (By similarity) (416 aa) | |||
TMPRSS11A | transmembrane protease, serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest (421 aa) | |||
CTRB1 | chymotrypsinogen B1 (263 aa) | |||
PRSS38 | protease, serine, 38 (326 aa) | |||
F10 | coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (488 aa) | |||
KLK7 | kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines (253 aa) | |||
TMPRSS2 | transmembrane protease, serine 2 (529 aa) | |||
ENSG00000184761 | Uncharacterized protein (149 aa) | |||
CFB | complement factor B (764 aa) | |||
SERPINE3 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity) (424 aa) | |||
KLK15 | kallikrein-related peptidase 15; Protease whose physiological substrate is not yet known (256 aa) | |||
KLK11 | kallikrein-related peptidase 11; Possible multifunctional protease. Efficiently cleaves ’bz-Phe-Arg-4-methylcoumaryl-7-amide’, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues (282 aa) |