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CORO1C CORO1C CORO1B CORO1B CORO2B CORO2B UBL4A UBL4A GABARAPL1 GABARAPL1 PMPCB PMPCB CORO2A CORO2A SLC25A3 SLC25A3 UBC UBC OAS1 OAS1 OAS2 OAS2 UQCRC1 UQCRC1 UBB UBB SLC25A28 SLC25A28 UBL4B UBL4B RHOT2 RHOT2 OXA1L OXA1L RHOT1 RHOT1 CORO1A CORO1A MINOS1 MINOS1 MRPL33 MRPL33 LETM2 LETM2 CDC73 CDC73 SLC25A37 SLC25A37 UBBP4 UBBP4 CORO6 CORO6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UQCRC1ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (480 aa)
CORO1Acoronin, actin binding protein, 1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (461 aa)
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (362 aa)
PMPCBpeptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (489 aa)
CORO1Ccoronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) (474 aa)
GABARAPL1GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles (117 aa)
OXA1Loxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (495 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
UBBubiquitin B (229 aa)
RHOT2ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa)
MINOS1mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) (78 aa)
UBL4Bubiquitin-like 4B (174 aa)
CORO1Bcoronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) (489 aa)
OAS22’-5’-oligoadenylate synthetase 2, 69/71kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2’-5’-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the [...] (719 aa)
CORO2Acoronin, actin binding protein, 2A (525 aa)
CORO6coronin 6 (472 aa)
UBCubiquitin C (685 aa)
RHOT1ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) (691 aa)
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and [...] (531 aa)
UBL4Aubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa)
SLC25A28solute carrier family 25 (mitochondrial iron transporter), member 28; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (364 aa)
OAS12’-5’-oligoadenylate synthetase 1, 40/46kDa (414 aa)
LETM2leucine zipper-EF-hand containing transmembrane protein 2 (444 aa)
SLC25A37solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (338 aa)
CORO2Bcoronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure (480 aa)
UBBP4ubiquitin B pseudogene 4 (229 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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