node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AES | HNF1A | ENSP00000221561 | ENSP00000257555 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | 0.954 |
AES | NKX6-3 | ENSP00000221561 | ENSP00000429553 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | 0.774 |
AES | TLE1 | ENSP00000221561 | ENSP00000365682 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.975 |
AES | TLE6 | ENSP00000221561 | ENSP00000246112 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) | 0.610 |
HNF1A | AES | ENSP00000257555 | ENSP00000221561 | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 0.954 |
HNF1A | HNF1B | ENSP00000257555 | ENSP00000225893 | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’ | 0.595 |
HNF1A | TLE1 | ENSP00000257555 | ENSP00000365682 | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.956 |
HNF1B | HNF1A | ENSP00000225893 | ENSP00000257555 | HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’ | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | 0.595 |
NKX6-3 | AES | ENSP00000429553 | ENSP00000221561 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 0.774 |
NKX6-3 | TLE1 | ENSP00000429553 | ENSP00000365682 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.774 |
NKX6-3 | TLE2 | ENSP00000429553 | ENSP00000262953 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.774 |
NKX6-3 | TLE3 | ENSP00000429553 | ENSP00000452871 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.779 |
NKX6-3 | TLE4 | ENSP00000429553 | ENSP00000365735 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.774 |
NKX6-3 | TLE6 | ENSP00000429553 | ENSP00000246112 | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) | 0.774 |
TLE1 | AES | ENSP00000365682 | ENSP00000221561 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 0.975 |
TLE1 | HNF1A | ENSP00000365682 | ENSP00000257555 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | 0.956 |
TLE1 | NKX6-3 | ENSP00000365682 | ENSP00000429553 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | 0.774 |
TLE1 | TLE2 | ENSP00000365682 | ENSP00000262953 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.956 |
TLE1 | TLE4 | ENSP00000365682 | ENSP00000365735 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.901 |
TLE2 | NKX6-3 | ENSP00000262953 | ENSP00000429553 | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity) | 0.774 |