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STRINGSTRING
WDR33 WDR33 WDR59 WDR59 GNB1L GNB1L C22orf25 C22orf25 IFT80 IFT80 EML4 EML4 SSBP1 SSBP1 TBL2 TBL2 UBC UBC DDB2 DDB2 WDR48 WDR48 WDR20 WDR20 KIAA1239 KIAA1239 TBL1XR1 TBL1XR1 DMWD DMWD WDFY2 WDFY2 USP35 USP35 HIP1R HIP1R EML6 EML6 HIP1 HIP1 WAS WAS WASL WASL NWD1 NWD1 BRWD3 BRWD3 ENSG00000248710 ENSG00000248710 WDFY1 WDFY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
WASLWiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa)
WDFY1WD repeat and FYVE domain containing 1 (410 aa)
HIP1Rhuntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (1068 aa)
DDB2damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex [...] (427 aa)
WDR59WD repeat domain 59 (974 aa)
SSBP1single-stranded DNA binding protein 1, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA (148 aa)
DMWDdystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis (674 aa)
WDFY2WD repeat and FYVE domain containing 2 (400 aa)
TBL2transducin (beta)-like 2 (447 aa)
WDR48WD repeat domain 48 (677 aa)
KIAA1239KIAA1239 (1742 aa)
IFT80intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)
EML4echinoderm microtubule associated protein like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) (981 aa)
WDR33WD repeat domain 33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends (1336 aa)
GNB1Lguanine nucleotide binding protein (G protein), beta polypeptide 1-like (327 aa)
C22orf25chromosome 22 open reading frame 25 (276 aa)
HIP1huntingtin interacting protein 1 (1037 aa)
UBCubiquitin C (685 aa)
EML6echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) (1958 aa)
BRWD3bromodomain and WD repeat domain containing 3 (1802 aa)
WASWiskott-Aldrich syndrome; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (502 aa)
NWD1NACHT and WD repeat domain containing 1 (1432 aa)
TBL1XR1transducin (beta)-like 1 X-linked receptor 1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (514 aa)
WDR20WD repeat domain 20 (600 aa)
USP35ubiquitin specific peptidase 35 (1018 aa)
ENSG00000248710Uncharacterized protein (948 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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