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WASL | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa) | |||
WDFY1 | WD repeat and FYVE domain containing 1 (410 aa) | |||
HIP1R | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (1068 aa) | |||
DDB2 | damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex [...] (427 aa) | |||
WDR59 | WD repeat domain 59 (974 aa) | |||
SSBP1 | single-stranded DNA binding protein 1, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA (148 aa) | |||
DMWD | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis (674 aa) | |||
WDFY2 | WD repeat and FYVE domain containing 2 (400 aa) | |||
TBL2 | transducin (beta)-like 2 (447 aa) | |||
WDR48 | WD repeat domain 48 (677 aa) | |||
KIAA1239 | KIAA1239 (1742 aa) | |||
IFT80 | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa) | |||
EML4 | echinoderm microtubule associated protein like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) (981 aa) | |||
WDR33 | WD repeat domain 33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends (1336 aa) | |||
GNB1L | guanine nucleotide binding protein (G protein), beta polypeptide 1-like (327 aa) | |||
C22orf25 | chromosome 22 open reading frame 25 (276 aa) | |||
HIP1 | huntingtin interacting protein 1 (1037 aa) | |||
UBC | ubiquitin C (685 aa) | |||
EML6 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) (1958 aa) | |||
BRWD3 | bromodomain and WD repeat domain containing 3 (1802 aa) | |||
WAS | Wiskott-Aldrich syndrome; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (502 aa) | |||
NWD1 | NACHT and WD repeat domain containing 1 (1432 aa) | |||
TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (514 aa) | |||
WDR20 | WD repeat domain 20 (600 aa) | |||
USP35 | ubiquitin specific peptidase 35 (1018 aa) | |||
ENSG00000248710 | Uncharacterized protein (948 aa) |