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TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 (124 aa) | |||
ACTN4 | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (911 aa) | |||
PITPNM3 | PITPNM family member 3; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions (974 aa) | |||
SPTBN4 | spectrin, beta, non-erythrocytic 4 (2564 aa) | |||
EHBP1 | EH domain binding protein 1 (1231 aa) | |||
DGKI | diacylglycerol kinase, iota (1065 aa) | |||
LRRK2 | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa) | |||
ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) (2743 aa) | |||
PROP1 | PROP paired-like homeobox 1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes (226 aa) | |||
SPTBN2 | spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa) | |||
EHBP1L1 | EH domain binding protein 1-like 1 (1523 aa) | |||
PITPNA | phosphatidylinositol transfer protein, alpha; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes (270 aa) | |||
SPTBN5 | spectrin, beta, non-erythrocytic 5 (3674 aa) | |||
PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (1349 aa) | |||
PITPNB | phosphatidylinositol transfer protein, beta; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes (271 aa) | |||
PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro (332 aa) | |||
PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Gol [...] (1244 aa) | |||
SPTBN1 | spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa) | |||
ACTN2 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa) | |||
SPTA1 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa) | |||
SPTAN1 | spectrin, alpha, non-erythrocytic 1 (2477 aa) | |||
ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (2671 aa) | |||
ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) (2701 aa) | |||
ACTN1 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (914 aa) | |||
DGKZ | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (1117 aa) | |||
ENSG00000254469 | Putative short transient receptor potential channel 2-like protein (206 aa) |