node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EML4 | KIRREL3 | ENSP00000320663 | ENSP00000435466 | echinoderm microtubule associated protein like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.533 |
KIRREL2 | KIRREL3 | ENSP00000353331 | ENSP00000435466 | kin of IRRE like 2 (Drosophila) | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.909 |
KIRREL2 | NPHS1 | ENSP00000353331 | ENSP00000368190 | kin of IRRE like 2 (Drosophila) | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | 0.853 |
KIRREL2 | NPHS2 | ENSP00000353331 | ENSP00000356587 | kin of IRRE like 2 (Drosophila) | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.862 |
KIRREL2 | TANC1 | ENSP00000353331 | ENSP00000263635 | kin of IRRE like 2 (Drosophila) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) | 0.749 |
KIRREL2 | TANC2 | ENSP00000353331 | ENSP00000387593 | kin of IRRE like 2 (Drosophila) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.749 |
KIRREL2 | TJP1 | ENSP00000353331 | ENSP00000281537 | kin of IRRE like 2 (Drosophila) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.448 |
KIRREL2 | WDR20 | ENSP00000353331 | ENSP00000406084 | kin of IRRE like 2 (Drosophila) | WD repeat domain 20 | 0.423 |
KIRREL3 | EML4 | ENSP00000435466 | ENSP00000320663 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | echinoderm microtubule associated protein like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.533 |
KIRREL3 | KIRREL2 | ENSP00000435466 | ENSP00000353331 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | kin of IRRE like 2 (Drosophila) | 0.909 |
KIRREL3 | NPHS1 | ENSP00000435466 | ENSP00000368190 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | 0.864 |
KIRREL3 | NPHS2 | ENSP00000435466 | ENSP00000356587 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.937 |
KIRREL3 | TANC1 | ENSP00000435466 | ENSP00000263635 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) | 0.749 |
KIRREL3 | TANC2 | ENSP00000435466 | ENSP00000387593 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.749 |
KIRREL3 | TJP1 | ENSP00000435466 | ENSP00000281537 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.462 |
NPHS1 | KIRREL2 | ENSP00000368190 | ENSP00000353331 | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | kin of IRRE like 2 (Drosophila) | 0.853 |
NPHS1 | KIRREL3 | ENSP00000368190 | ENSP00000435466 | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.864 |
NPHS1 | NPHS2 | ENSP00000368190 | ENSP00000356587 | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.999 |
NPHS1 | TJP1 | ENSP00000368190 | ENSP00000281537 | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.968 |
NPHS2 | KIRREL2 | ENSP00000356587 | ENSP00000353331 | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | kin of IRRE like 2 (Drosophila) | 0.862 |