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STRINGSTRING
CLDN22 CLDN22 CLDN25 CLDN25 ENSG00000262302 ENSG00000262302 CLDN17 CLDN17 CLDN24 CLDN24 MAX MAX CLDN10 CLDN10 CLDN16 CLDN16 CLDN15 CLDN15 CLDN18 CLDN18 ZBTB17 ZBTB17 CLDN19 CLDN19 MYC MYC CLDN8 CLDN8 CLDN11 CLDN11 CLDN14 CLDN14 CLDN5 CLDN5 TJP2 TJP2 TJP1 TJP1 EPB41L3 EPB41L3 OCLN OCLN CGN CGN EPB41L1 EPB41L1 SPTAN1 SPTAN1 CTNNA3 CTNNA3 CTNNA2 CTNNA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CLDN11claudin 11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (207 aa)
CLDN18claudin 18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (261 aa)
CLDN16claudin 16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (305 aa)
CGNcingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (1203 aa)
TJP1tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (1748 aa)
CLDN17claudin 17; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (224 aa)
CLDN8claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) (225 aa)
CLDN19claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (224 aa)
CLDN10claudin 10; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (228 aa)
CLDN15claudin 15; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (228 aa)
CLDN22claudin 22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (220 aa)
EPB41L1erythrocyte membrane protein band 4.1-like 1 (881 aa)
CLDN14claudin 14; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (239 aa)
EPB41L3erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas (1087 aa)
OCLNoccludin (522 aa)
MAXMYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity (160 aa)
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)
CTNNA3catenin (cadherin-associated protein), alpha 3; May be involved in formation of stretch-resistant cell- cell adhesion complexes (895 aa)
ZBTB17zinc finger and BTB domain containing 17; Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during [...] (803 aa)
MYCv-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa)
CLDN5claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) (303 aa)
CLDN25claudin 25; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (229 aa)
CTNNA2catenin (cadherin-associated protein), alpha 2 (905 aa)
TJP2tight junction protein 2 (1221 aa)
CLDN24claudin 24; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (220 aa)
ENSG00000262302Uncharacterized protein (83 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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