node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKLE2 | LEMD2 | ENSP00000350686 | ENSP00000293760 | ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex | LEM domain containing 2; Involved in nuclear structure organization | 0.543 |
ANKLE2 | LEMD3 | ENSP00000350686 | ENSP00000308369 | ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex | LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest | 0.488 |
ANKLE2 | VRK1 | ENSP00000350686 | ENSP00000216639 | ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex | vaccinia related kinase 1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle- following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates ’Thr- 18’ of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1- disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm | 0.943 |
BANF2 | CSNK1A1 | ENSP00000439128 | ENSP00000421689 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | casein kinase 1, alpha 1 | 0.545 |
BANF2 | CSNK1A1L | ENSP00000439128 | ENSP00000369126 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | casein kinase 1, alpha 1-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | 0.545 |
BANF2 | CSNK1D | ENSP00000439128 | ENSP00000324464 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | casein kinase 1, delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator [...] | 0.545 |
BANF2 | CSNK1E | ENSP00000439128 | ENSP00000352929 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.545 |
BANF2 | LEMD2 | ENSP00000439128 | ENSP00000293760 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | LEM domain containing 2; Involved in nuclear structure organization | 0.509 |
BANF2 | LEMD3 | ENSP00000439128 | ENSP00000308369 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest | 0.570 |
BANF2 | RBM23 | ENSP00000439128 | ENSP00000352956 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process | 0.509 |
BANF2 | RBM39 | ENSP00000439128 | ENSP00000253363 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | RNA binding motif protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process | 0.509 |
BANF2 | TTBK1 | ENSP00000439128 | ENSP00000259750 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | tau tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU | 0.545 |
BANF2 | TTBK2 | ENSP00000439128 | ENSP00000267890 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | tau tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.545 |
BANF2 | VRK1 | ENSP00000439128 | ENSP00000216639 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | vaccinia related kinase 1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle- following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates ’Thr- 18’ of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1- disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm | 0.561 |
BANF2 | VRK2 | ENSP00000439128 | ENSP00000342381 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | vaccinia related kinase 2 | 0.545 |
BANF2 | VRK3 | ENSP00000439128 | ENSP00000324636 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | vaccinia related kinase 3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus (By similarity) | 0.545 |
CSNK1A1 | BANF2 | ENSP00000421689 | ENSP00000439128 | casein kinase 1, alpha 1 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | 0.545 |
CSNK1A1 | CSNK1D | ENSP00000421689 | ENSP00000324464 | casein kinase 1, alpha 1 | casein kinase 1, delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator [...] | 0.740 |
CSNK1A1 | CSNK1E | ENSP00000421689 | ENSP00000352929 | casein kinase 1, alpha 1 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.598 |
CSNK1A1L | BANF2 | ENSP00000369126 | ENSP00000439128 | casein kinase 1, alpha 1-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 | 0.545 |