node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | NCOR1 | ENSP00000270202 | ENSP00000268712 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.873 |
AKT1 | PARK2 | ENSP00000270202 | ENSP00000355865 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.650 |
AKT1 | RPS27A | ENSP00000270202 | ENSP00000272317 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | ribosomal protein S27a | 0.966 |
AKT1 | UBA52 | ENSP00000270202 | ENSP00000388107 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | ubiquitin A-52 residue ribosomal protein fusion product 1 | 0.906 |
AKT1 | UBC | ENSP00000270202 | ENSP00000344818 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | ubiquitin C | 0.999 |
DHX33 | DHX37 | ENSP00000225296 | ENSP00000311135 | DEAH (Asp-Glu-Ala-His) box polypeptide 33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | 0.484 |
DHX33 | UBC | ENSP00000225296 | ENSP00000344818 | DEAH (Asp-Glu-Ala-His) box polypeptide 33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization | ubiquitin C | 0.779 |
DHX37 | DHX33 | ENSP00000311135 | ENSP00000225296 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | DEAH (Asp-Glu-Ala-His) box polypeptide 33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization | 0.484 |
DHX37 | DHX8 | ENSP00000311135 | ENSP00000262415 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.610 |
DHX37 | UBC | ENSP00000311135 | ENSP00000344818 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | ubiquitin C | 0.509 |
DHX37 | WBSCR22 | ENSP00000311135 | ENSP00000401191 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | Williams Beuren syndrome chromosome region 22 | 0.488 |
DHX37 | WBSCR27 | ENSP00000311135 | ENSP00000297873 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | Williams Beuren syndrome chromosome region 27 | 0.456 |
DHX37 | YTHDC2 | ENSP00000311135 | ENSP00000161863 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | YTH domain containing 2 | 0.551 |
DHX8 | DHX37 | ENSP00000262415 | ENSP00000311135 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | 0.610 |
DHX8 | MRPS5 | ENSP00000262415 | ENSP00000272418 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | mitochondrial ribosomal protein S5 | 0.575 |
DHX8 | RPS2 | ENSP00000262415 | ENSP00000341885 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | ribosomal protein S2 | 0.576 |
DHX8 | UBC | ENSP00000262415 | ENSP00000344818 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | ubiquitin C | 0.517 |
HCFC1 | PDCD2 | ENSP00000309555 | ENSP00000439467 | host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] | programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation | 0.625 |
HCFC1 | UBC | ENSP00000309555 | ENSP00000344818 | host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] | ubiquitin C | 0.935 |
MRPS5 | DHX8 | ENSP00000272418 | ENSP00000262415 | mitochondrial ribosomal protein S5 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.575 |