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STRINGSTRING
WBSCR27 WBSCR27 WBSCR22 WBSCR22 YTHDC2 YTHDC2 METTL21C METTL21C DHX37 DHX37 DHX33 DHX33 ENSG00000267168 ENSG00000267168 ERRFI1 ERRFI1 DHX8 DHX8 HCFC1 HCFC1 UBC UBC PDCD2 PDCD2 RPS2 RPS2 MRPS5 MRPS5 USP49 USP49 PARK2 PARK2 NAA38 NAA38 NCOR1 NCOR1 UBA52 UBA52 USP43 USP43 SETD2 SETD2 AKT1 AKT1 RPS27A RPS27A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
YTHDC2YTH domain containing 2 (1430 aa)
DHX33DEAH (Asp-Glu-Ala-His) box polypeptide 33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization (707 aa)
NAA38N(alpha)-acetyltransferase 38, NatC auxiliary subunit; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome (96 aa)
DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (1220 aa)
METTL21Cmethyltransferase like 21C; Protein-lysine methyltransferase (264 aa)
NCOR1nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors (2440 aa)
AKT1v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa)
RPS27Aribosomal protein S27a (156 aa)
MRPS5mitochondrial ribosomal protein S5 (430 aa)
USP43ubiquitin specific peptidase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity) (1123 aa)
USP49ubiquitin specific peptidase 49 (640 aa)
WBSCR27Williams Beuren syndrome chromosome region 27 (245 aa)
HCFC1host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] (2035 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
RPS2ribosomal protein S2 (293 aa)
UBCubiquitin C (685 aa)
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin) (465 aa)
ERRFI1ERBB receptor feedback inhibitor 1; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus [...] (462 aa)
SETD2SET domain containing 2 (2564 aa)
UBA52ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa)
WBSCR22Williams Beuren syndrome chromosome region 22 (298 aa)
PDCD2programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation (344 aa)
ENSG00000267168Uncharacterized protein (100 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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