| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | CSMD1 | ENSP00000285930 | ENSP00000441462 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | 0.493 |
| APAF1 | CSMD1 | ENSP00000448165 | ENSP00000441462 | apoptotic peptidase activating factor 1 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | 0.576 |
| APAF1 | TP53 | ENSP00000448165 | ENSP00000269305 | apoptotic peptidase activating factor 1 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.996 |
| BCL6 | TP53 | ENSP00000232014 | ENSP00000269305 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.992 |
| C3 | C4A | ENSP00000245907 | ENSP00000396688 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 4A (Rodgers blood group) | 0.919 |
| C3 | C4B | ENSP00000245907 | ENSP00000415941 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 4B (Chido blood group) | 0.849 |
| C3 | C5 | ENSP00000245907 | ENSP00000223642 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | 0.960 |
| C4A | C3 | ENSP00000396688 | ENSP00000245907 | complement component 4A (Rodgers blood group) | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.919 |
| C4B | C3 | ENSP00000415941 | ENSP00000245907 | complement component 4B (Chido blood group) | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.849 |
| C5 | C3 | ENSP00000223642 | ENSP00000245907 | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.960 |
| CSMD1 | AKR1B1 | ENSP00000441462 | ENSP00000285930 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.493 |
| CSMD1 | APAF1 | ENSP00000441462 | ENSP00000448165 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | apoptotic peptidase activating factor 1 | 0.576 |
| CSMD1 | HNRNPU | ENSP00000441462 | ENSP00000283179 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | 0.564 |
| CSMD1 | TP53 | ENSP00000441462 | ENSP00000269305 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.614 |
| HNRNPU | CSMD1 | ENSP00000283179 | ENSP00000441462 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | 0.564 |
| TP53 | APAF1 | ENSP00000269305 | ENSP00000448165 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | apoptotic peptidase activating factor 1 | 0.996 |
| TP53 | BCL6 | ENSP00000269305 | ENSP00000232014 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.992 |
| TP53 | CSMD1 | ENSP00000269305 | ENSP00000441462 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas | 0.614 |
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