node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EML2 | EXD1 | ENSP00000442365 | ENSP00000321029 | echinoderm microtubule associated protein like 2; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | exonuclease 3’-5’ domain containing 1 | 0.612 |
EML2 | NEK6 | ENSP00000442365 | ENSP00000362702 | echinoderm microtubule associated protein like 2; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence | 0.443 |
EML3 | NEK6 | ENSP00000378254 | ENSP00000362702 | echinoderm microtubule associated protein like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence | 0.435 |
EXD1 | EML2 | ENSP00000321029 | ENSP00000442365 | exonuclease 3’-5’ domain containing 1 | echinoderm microtubule associated protein like 2; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.612 |
NEK6 | EML2 | ENSP00000362702 | ENSP00000442365 | NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence | echinoderm microtubule associated protein like 2; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.443 |
NEK6 | EML3 | ENSP00000362702 | ENSP00000378254 | NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence | echinoderm microtubule associated protein like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.435 |
TUBA1C | TUBB2A | ENSP00000301072 | ENSP00000369703 | tubulin, alpha 1c; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | tubulin, beta 2A class IIa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.982 |
TUBA1C | TUBB2B | ENSP00000301072 | ENSP00000259818 | tubulin, alpha 1c; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | tubulin, beta 2B class IIb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration | 0.963 |
TUBB2A | TUBA1C | ENSP00000369703 | ENSP00000301072 | tubulin, beta 2A class IIa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | tubulin, alpha 1c; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.982 |
TUBB2A | TUBB2B | ENSP00000369703 | ENSP00000259818 | tubulin, beta 2A class IIa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | tubulin, beta 2B class IIb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration | 0.900 |
TUBB2B | TUBA1C | ENSP00000259818 | ENSP00000301072 | tubulin, beta 2B class IIb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration | tubulin, alpha 1c; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.963 |
TUBB2B | TUBB2A | ENSP00000259818 | ENSP00000369703 | tubulin, beta 2B class IIb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration | tubulin, beta 2A class IIa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.900 |