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RAB33A RAB33A SEC22A SEC22A RAB1B RAB1B SEC22C SEC22C SH3YL1 SH3YL1 RABGAP1 RABGAP1 RAB1A RAB1A RAB10 RAB10 RAB33B RAB33B USP6NL USP6NL RABEP1 RABEP1 RABGAP1L RABGAP1L USP6 USP6 RABEP2 RABEP2 TBC1D3F TBC1D3F EVI5L EVI5L TBC1D28 TBC1D28 TBC1D3C TBC1D3C TBC1D26 TBC1D26 TBC1D29 TBC1D29 TBC1D3 TBC1D3 TBC1D3H TBC1D3H SRPK2 SRPK2 NUDT18 NUDT18 TBC1D3G TBC1D3G TBC1D3B TBC1D3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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USP6ubiquitin specific peptidase 6 (Tre-2 oncogene); Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation (1406 aa)
RABGAP1LRAB GTPase activating protein 1-like (815 aa)
RAB33ARAB33A, member RAS oncogene family (237 aa)
RABEP1rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A (862 aa)
SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (303 aa)
RAB10RAB10, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transpo [...] (200 aa)
USP6NLUSP6 N-terminal like; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (845 aa)
RAB33BRAB33B, member RAS oncogene family; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation (229 aa)
NUDT18nudix (nucleoside diphosphate linked moiety X)-type motif 18; Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (323 aa)
RAB1BRAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
TBC1D3FTBC1 domain family, member 3F; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D28TBC1 domain family, member 28 (210 aa)
TBC1D3GTBC1 domain family, member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D3TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (549 aa)
SH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (342 aa)
RABEP2rabaptin, RAB GTPase binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion (569 aa)
RABGAP1RAB GTPase activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition (1069 aa)
SRPK2SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] (699 aa)
TBC1D3BTBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
RAB1ARAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa)
TBC1D3CTBC1 domain family, member 3C; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D3HTBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
TBC1D26TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) (250 aa)
EVI5Lecotropic viral integration site 5-like; Functions as a GTPase-activating protein (GAP) with a broad specificity (805 aa)
TBC1D29TBC1 domain family, member 29 (150 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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