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TEKT2 | tektin 2 (testicular); Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity) (430 aa) | |||
ADH1A | alcohol dehydrogenase 1A (class I), alpha polypeptide (375 aa) | |||
IYD | iodotyrosine deiodinase (293 aa) | |||
TP53I3 | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) (332 aa) | |||
ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 (385 aa) | |||
MECR | mitochondrial trans-2-enoyl-CoA reductase; Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids (373 aa) | |||
MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state (725 aa) | |||
ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa) | |||
SORD | sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity) (357 aa) | |||
ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (374 aa) | |||
VAT1L | vesicle amine transport protein 1 homolog (T. californica)-like (419 aa) | |||
ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa) | |||
SPERT | spermatid associated (448 aa) | |||
CRYZ | crystallin, zeta (quinone reductase); Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3’-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding (329 aa) | |||
MRRF | mitochondrial ribosome recycling factor (262 aa) | |||
VAT1 | vesicle amine transport protein 1 homolog (T. californica); Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (393 aa) | |||
RTN4IP1 | reticulon 4 interacting protein 1; Appears to be a potent inhibitor of regeneration following spinal cord injury (396 aa) | |||
FAF1 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis (650 aa) | |||
CRYZL1 | crystallin, zeta (quinone reductase)-like 1 (349 aa) | |||
ADH6 | alcohol dehydrogenase 6 (class V) (375 aa) | |||
ADHFE1 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities (467 aa) | |||
HADH | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa) | |||
ADH7 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa) | |||
MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type (250 aa) | |||
ENSG00000257767 | Uncharacterized protein (245 aa) | |||
ENSG00000269469 | Uncharacterized protein (72 aa) |