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ADAM7 | ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity) (754 aa) | |||
ADAM11 | ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (769 aa) | |||
REEP6 | receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) (184 aa) | |||
HCST | hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] (93 aa) | |||
DAD1 | defender against cell death 1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity) (113 aa) | |||
EMC8 | ER membrane protein complex subunit 8 (210 aa) | |||
ADAMDEC1 | ADAM-like, decysin 1; May play an important role in the control of the immune response and during pregnancy (By similarity) (470 aa) | |||
ADAM19 | ADAM metallopeptidase domain 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity) (918 aa) | |||
TYROBP | TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin (113 aa) | |||
ADAM23 | ADAM metallopeptidase domain 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (832 aa) | |||
ADAM22 | ADAM metallopeptidase domain 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1 (906 aa) | |||
ADAM28 | ADAM metallopeptidase domain 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation (775 aa) | |||
CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption (235 aa) | |||
CD276 | CD276 molecule; May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modula [...] (534 aa) | |||
BCAN | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans (911 aa) | |||
ADAM33 | ADAM metallopeptidase domain 33 (813 aa) | |||
ADAM15 | ADAM metallopeptidase domain 15 (863 aa) | |||
ADAM12 | ADAM metallopeptidase domain 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity) (909 aa) | |||
TSPAN6 | tetraspanin 6 (245 aa) | |||
F7 | coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (466 aa) | |||
YIF1A | Yip1 interacting factor homolog A (S. cerevisiae); Possible role in transport between endoplasmic reticulum and Golgi (293 aa) | |||
PTRH2 | peptidyl-tRNA hydrolase 2; The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) (179 aa) | |||
TMBIM6 | transmembrane BAX inhibitor motif containing 6; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel (295 aa) | |||
ADAM9 | ADAM metallopeptidase domain 9; Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP (819 aa) | |||
CLEC5A | C-type lectin domain family 5, member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release (188 aa) | |||
ADAM8 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes (824 aa) |