Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter (496 aa) | ||
 | UMPS | uridine monophosphate synthetase (480 aa) | ||
 | SLC2A9 | solute carrier family 2 (facilitated glucose transporter), member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate (540 aa) | ||
 | RPS27A | ribosomal protein S27a (156 aa) | ||
 | MFSD3 | major facilitator superfamily domain containing 3 (412 aa) | ||
 | OXSR1 | oxidative-stress responsive 1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton (527 aa) | ||
 | SLC16A6 | solute carrier family 16, member 6 (monocarboxylic acid transporter 7); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (523 aa) | ||
 | SLC16A8 | solute carrier family 16, member 8 (monocarboxylic acid transporter 3); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (504 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | STK39 | serine threonine kinase 39; May act as a mediator of stress-activated signals (545 aa) | ||
 | SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1; Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides (549 aa) | ||
 | SLC22A2 | solute carrier family 22 (organic cation transporter), member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited b [...] (555 aa) | ||
 | SLC22A1 | solute carrier family 22 (organic cation transporter), member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), coca [...] (554 aa) | ||
 | MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) (978 aa) | ||
 | SLC16A1 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (500 aa) | ||
 | ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 (795 aa) | ||
 | SLC16A12 | solute carrier family 16, member 12 (monocarboxylic acid transporter 12); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (516 aa) | ||
 | SLC22A7 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate (548 aa) | ||
 | SLC22A12 | solute carrier family 22 (organic anion/urate transporter), member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions (553 aa) | ||
 | SLC22A6 | solute carrier family 22 (organic anion transporter), member 6 (563 aa) | ||
 | SLC2A7 | solute carrier family 2 (facilitated glucose transporter), member 7; High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose (512 aa) | ||
 | ENSG00000251357 | Uncharacterized protein (176 aa) | ||
 | MFSD1 | major facilitator superfamily domain containing 1 (514 aa) | ||
 | SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (492 aa) | ||
 | MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa) | ||
 | SLC12A6 | solute carrier family 12 (potassium/chloride transporters), member 6 (1141 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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