| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AANAT | DDC | ENSP00000250615 | ENSP00000350616 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | 0.933 |
| AANAT | ENSG00000254959 | ENSP00000250615 | ENSP00000456039 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | INMT-FAM188B readthrough (non-protein coding) | 0.900 |
| AANAT | IDO1 | ENSP00000250615 | ENSP00000430505 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | 0.906 |
| AANAT | IDO2 | ENSP00000250615 | ENSP00000443432 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism | 0.900 |
| AANAT | MAOA | ENSP00000250615 | ENSP00000340684 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.923 |
| AANAT | MAOB | ENSP00000250615 | ENSP00000367309 | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.917 |
| ABP1 | DDC | ENSP00000354193 | ENSP00000350616 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | 0.900 |
| ABP1 | ENSG00000254959 | ENSP00000354193 | ENSP00000456039 | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | INMT-FAM188B readthrough (non-protein coding) | 0.900 |
| DDC | AANAT | ENSP00000350616 | ENSP00000250615 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | 0.933 |
| DDC | ABP1 | ENSP00000350616 | ENSP00000354193 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | 0.900 |
| DDC | ENSG00000254959 | ENSP00000350616 | ENSP00000456039 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | INMT-FAM188B readthrough (non-protein coding) | 0.900 |
| DDC | IDO1 | ENSP00000350616 | ENSP00000430505 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | 0.903 |
| DDC | IDO2 | ENSP00000350616 | ENSP00000443432 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism | 0.900 |
| DDC | MAOA | ENSP00000350616 | ENSP00000340684 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.957 |
| DDC | MAOB | ENSP00000350616 | ENSP00000367309 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.963 |
| ENSG00000254959 | AANAT | ENSP00000456039 | ENSP00000250615 | INMT-FAM188B readthrough (non-protein coding) | aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin | 0.900 |
| ENSG00000254959 | ABP1 | ENSP00000456039 | ENSP00000354193 | INMT-FAM188B readthrough (non-protein coding) | amiloride binding protein 1 (amine oxidase (copper-containing)); Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function | 0.900 |
| ENSG00000254959 | DDC | ENSP00000456039 | ENSP00000350616 | INMT-FAM188B readthrough (non-protein coding) | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | 0.900 |
| ENSG00000254959 | IDO1 | ENSP00000456039 | ENSP00000430505 | INMT-FAM188B readthrough (non-protein coding) | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | 0.900 |
| ENSG00000254959 | IDO2 | ENSP00000456039 | ENSP00000443432 | INMT-FAM188B readthrough (non-protein coding) | indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism | 0.900 |
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