node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANAPC4 | BUB1B | ENSP00000318775 | ENSP00000287598 | anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.999 |
ANAPC4 | SLC25A24 | ENSP00000318775 | ENSP00000457733 | anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.575 |
ANAPC4 | UBC | ENSP00000318775 | ENSP00000344818 | anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | ubiquitin C | 0.961 |
BUB1B | ANAPC4 | ENSP00000287598 | ENSP00000318775 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | anaphase promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.999 |
BUB1B | PARK2 | ENSP00000287598 | ENSP00000355865 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.505 |
BUB1B | SLC25A24 | ENSP00000287598 | ENSP00000457733 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.575 |
BUB1B | UBC | ENSP00000287598 | ENSP00000344818 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | ubiquitin C | 0.990 |
CD55 | MPV17 | ENSP00000316333 | ENSP00000233545 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance | 0.540 |
CD55 | SLC25A24 | ENSP00000316333 | ENSP00000457733 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.905 |
COX15 | SURF1 | ENSP00000016171 | ENSP00000361042 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.916 |
COX15 | UBC | ENSP00000016171 | ENSP00000344818 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | ubiquitin C | 0.627 |
FAF2 | SLC25A22 | ENSP00000261942 | ENSP00000322020 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | solute carrier family 25 (mitochondrial carrier- glutamate), member 22 | 0.644 |
FAF2 | SLC25A24 | ENSP00000261942 | ENSP00000457733 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.644 |
FAF2 | UBC | ENSP00000261942 | ENSP00000344818 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | ubiquitin C | 0.991 |
HNRNPM | SLC25A24 | ENSP00000325376 | ENSP00000457733 | heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.644 |
HNRNPM | UBC | ENSP00000325376 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines | ubiquitin C | 0.992 |
MPV17 | CD55 | ENSP00000233545 | ENSP00000316333 | MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | 0.540 |
MPV17 | SLC25A24 | ENSP00000233545 | ENSP00000457733 | MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria | 0.644 |
PARK2 | BUB1B | ENSP00000355865 | ENSP00000287598 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.505 |
PARK2 | UBC | ENSP00000355865 | ENSP00000344818 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin C | 0.999 |