Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RPS5 | ribosomal protein S5 (204 aa) | ||
 | RPL6 | ribosomal protein L6; Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (288 aa) | ||
 | SRP54 | signal recognition particle 54kDa; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (504 aa) | ||
 | RPL18A | ribosomal protein L18a (176 aa) | ||
 | SEC61B | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum (96 aa) | ||
 | RPL19 | ribosomal protein L19 (196 aa) | ||
 | ISL1 | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa) | ||
 | SSR1 | signal sequence receptor, alpha (286 aa) | ||
 | RPS4Y1 | ribosomal protein S4, Y-linked 1 (263 aa) | ||
 | SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein); Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa) | ||
 | SEC11A | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (179 aa) | ||
 | RPL3L | ribosomal protein L3-like (407 aa) | ||
 | RPS11 | ribosomal protein S11 (158 aa) | ||
 | RPL37 | ribosomal protein L37; Binds to the 23S rRNA (By similarity) (97 aa) | ||
 | RPL30 | ribosomal protein L30 (115 aa) | ||
 | RPL26 | ribosomal protein L26 (145 aa) | ||
 | RPL29 | ribosomal protein L29 (159 aa) | ||
 | SSR2 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins (183 aa) | ||
 | RPS23 | ribosomal protein S23 (143 aa) | ||
 | SRP9 | signal recognition particle 9kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (86 aa) | ||
 | RPL13 | ribosomal protein L13 (211 aa) | ||
 | RPL15 | ribosomal protein L15 (204 aa) | ||
 | RPL38 | ribosomal protein L38 (70 aa) | ||
 | RPS14 | ribosomal protein S14 (151 aa) | ||
 | RPL4 | ribosomal protein L4 (427 aa) | ||
 | SEC11C | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (192 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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