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STRINGSTRING
SSR1 SSR1 RPS28 RPS28 RPL37 RPL37 RPL3L RPL3L RPL8 RPL8 RPS2 RPS2 RPL30 RPL30 SSR3 SSR3 RPN2 RPN2 RPS7 RPS7 RPL18 RPL18 RPL35A RPL35A SRP9 SRP9 RPS23 RPS23 SEC61B SEC61B TRAM1 TRAM1 RPL35 RPL35 RPL10A RPL10A SRP68 SRP68 RPL23 RPL23 RPL17 RPL17 RPS21 RPS21 RPLP2 RPLP2 RPS16 RPS16 SEC11C SEC11C PAX6 PAX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SEC61BSec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum (96 aa)
RPN2ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (631 aa)
SSR1signal sequence receptor, alpha (286 aa)
RPS16ribosomal protein S16 (146 aa)
RPL35ribosomal protein L35 (123 aa)
TRAM1translocation associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (374 aa)
RPL8ribosomal protein L8 (257 aa)
SSR3signal sequence receptor, gamma (translocon-associated protein gamma); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins (185 aa)
RPL3Lribosomal protein L3-like (407 aa)
RPL37ribosomal protein L37; Binds to the 23S rRNA (By similarity) (97 aa)
RPL30ribosomal protein L30 (115 aa)
RPS23ribosomal protein S23 (143 aa)
SRP9signal recognition particle 9kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (86 aa)
SRP68signal recognition particle 68kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (627 aa)
RPLP2ribosomal protein, large, P2; Plays an important role in the elongation step of protein synthesis (115 aa)
RPS7ribosomal protein S7; Required for rRNA maturation (194 aa)
RPS2ribosomal protein S2 (293 aa)
RPS21ribosomal protein S21 (83 aa)
RPL10Aribosomal protein L10a (217 aa)
PAX6paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes (436 aa)
RPL23ribosomal protein L23 (140 aa)
RPL35Aribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (110 aa)
RPL18ribosomal protein L18 (188 aa)
RPL17ribosomal protein L17 (184 aa)
SEC11CSEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (192 aa)
RPS28ribosomal protein S28 (69 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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