Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ZNF263 | zinc finger protein 263; Might play an important role in basic cellular processes as a transcriptional repressor (683 aa) | ||
 | ZNF232 | zinc finger protein 232; May be involved in transcriptional regulation (444 aa) | ||
 | PGBD1 | piggyBac transposable element derived 1 (809 aa) | ||
 | ZNF24 | zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro (368 aa) | ||
 | CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa) | ||
 | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chrom [...] (1590 aa) | ||
 | ZNF167 | zinc finger protein 167; May be involved in transcriptional regulation (754 aa) | ||
 | TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (1893 aa) | ||
 | ZSCAN21 | zinc finger and SCAN domain containing 21; Strong transcriptional activator (By similarity) (473 aa) | ||
 | ZNF496 | zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor (By similarity) (587 aa) | ||
 | ZNF396 | zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors (333 aa) | ||
 | ZNF434 | zinc finger protein 434; May be involved in transcriptional regulation (485 aa) | ||
 | FHL5 | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner (284 aa) | ||
 | ZSCAN30 | zinc finger and SCAN domain containing 30; May be involved in transcriptional regulation (494 aa) | ||
 | ZNF397 | zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor (534 aa) | ||
 | DGCR6 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches (220 aa) | ||
 | ZSCAN22 | zinc finger and SCAN domain containing 22; May be involved in transcriptional regulation (491 aa) | ||
 | PTGES | prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (152 aa) | ||
 | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephos [...] (1679 aa) | ||
 | SUFU | suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] (484 aa) | ||
 | ZSCAN16 | zinc finger and SCAN domain containing 16; May be involved in transcriptional regulation (348 aa) | ||
 | ZNF165 | zinc finger protein 165; May be involved in transcriptional regulation (485 aa) | ||
 | ZNF193 | zinc finger protein 193; May be involved in transcriptional regulation (445 aa) | ||
 | TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced (1826 aa) | ||
 | OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (8678 aa) | ||
 | ZNF446 | zinc finger protein 446; May be involved in transcriptional regulation (450 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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