node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | FDFT1 | ENSP00000003100 | ENSP00000220584 | cytochrome P450, family 51, subfamily A, polypeptide 1 | farnesyl-diphosphate farnesyltransferase 1 | 0.993 |
CYP51A1 | HSD17B7 | ENSP00000003100 | ENSP00000254521 | cytochrome P450, family 51, subfamily A, polypeptide 1 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols | 0.984 |
CYP51A1 | IDI1 | ENSP00000003100 | ENSP00000370748 | cytochrome P450, family 51, subfamily A, polypeptide 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.982 |
CYP51A1 | LBR | ENSP00000003100 | ENSP00000272163 | cytochrome P450, family 51, subfamily A, polypeptide 1 | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.992 |
CYP51A1 | LSS | ENSP00000003100 | ENSP00000348762 | cytochrome P450, family 51, subfamily A, polypeptide 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.999 |
CYP51A1 | MSMO1 | ENSP00000003100 | ENSP00000261507 | cytochrome P450, family 51, subfamily A, polypeptide 1 | methylsterol monooxygenase 1 | 0.997 |
CYP51A1 | SC5DL | ENSP00000003100 | ENSP00000264027 | cytochrome P450, family 51, subfamily A, polypeptide 1 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.993 |
CYP51A1 | SQLE | ENSP00000003100 | ENSP00000265896 | cytochrome P450, family 51, subfamily A, polypeptide 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.978 |
CYP51A1 | TM7SF2 | ENSP00000003100 | ENSP00000279263 | cytochrome P450, family 51, subfamily A, polypeptide 1 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.994 |
CYP51A1 | UBC | ENSP00000003100 | ENSP00000344818 | cytochrome P450, family 51, subfamily A, polypeptide 1 | ubiquitin C | 0.986 |
FDFT1 | CYP51A1 | ENSP00000220584 | ENSP00000003100 | farnesyl-diphosphate farnesyltransferase 1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.993 |
FDFT1 | HSD17B7 | ENSP00000220584 | ENSP00000254521 | farnesyl-diphosphate farnesyltransferase 1 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols | 0.976 |
FDFT1 | IDI1 | ENSP00000220584 | ENSP00000370748 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.848 |
FDFT1 | LBR | ENSP00000220584 | ENSP00000272163 | farnesyl-diphosphate farnesyltransferase 1 | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.728 |
FDFT1 | LSS | ENSP00000220584 | ENSP00000348762 | farnesyl-diphosphate farnesyltransferase 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.977 |
FDFT1 | MSMO1 | ENSP00000220584 | ENSP00000261507 | farnesyl-diphosphate farnesyltransferase 1 | methylsterol monooxygenase 1 | 0.993 |
FDFT1 | SC5DL | ENSP00000220584 | ENSP00000264027 | farnesyl-diphosphate farnesyltransferase 1 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.991 |
FDFT1 | SQLE | ENSP00000220584 | ENSP00000265896 | farnesyl-diphosphate farnesyltransferase 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.980 |
FDFT1 | TM7SF2 | ENSP00000220584 | ENSP00000279263 | farnesyl-diphosphate farnesyltransferase 1 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.800 |
FDFT1 | UBC | ENSP00000220584 | ENSP00000344818 | farnesyl-diphosphate farnesyltransferase 1 | ubiquitin C | 0.988 |