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SPCS2 SPCS2 MRPL36 MRPL36 ZZEF1 ZZEF1 ZBTB11 ZBTB11 GCFC2 GCFC2 FBXL17 FBXL17 WDR54 WDR54 ZNHIT3 ZNHIT3 ZFAND2A ZFAND2A TXNDC9 TXNDC9 DUS3L DUS3L
"WDR54" - WD repeat domain 54 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
WDR54WD repeat domain 54 (334 aa)    
Predicted Functional Partners:
MRPL36
mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa)
            score_image   0.655
FBXL17
F-box and leucine-rich repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (701 aa)
            score_image   0.652
ZNHIT3
zinc finger, HIT-type containing 3 (155 aa)
            score_image   0.643
ZBTB11
zinc finger and BTB domain containing 11; May be involved in transcriptional regulation (1053 aa)
            score_image   0.643
ZFAND2A
zinc finger, AN1-type domain 2A (145 aa)
            score_image   0.641
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (226 aa)
            score_image   0.630
GCFC2
GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters (781 aa)
            score_image   0.629
DUS3L
dihydrouridine synthase 3-like (S. cerevisiae); Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) (650 aa)
            score_image   0.594
ZZEF1
zinc finger, ZZ-type with EF-hand domain 1 (2961 aa)
            score_image   0.580
TXNDC9
thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin (226 aa)
            score_image   0.578
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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