node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPZA1 | CAPZA2 | ENSP00000263168 | ENSP00000354947 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.952 |
CAPZA1 | SATL1 | ENSP00000263168 | ENSP00000425421 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | spermidine/spermine N1-acetyl transferase-like 1 | 0.405 |
CAPZA1 | SPATA20 | ENSP00000263168 | ENSP00000006658 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.512 |
CAPZA1 | WDR63 | ENSP00000263168 | ENSP00000294664 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | WD repeat domain 63 | 0.507 |
CAPZA2 | CAPZA1 | ENSP00000354947 | ENSP00000263168 | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.952 |
CAPZA2 | SPATA20 | ENSP00000354947 | ENSP00000006658 | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.463 |
CASKIN1 | RBMXL2 | ENSP00000345436 | ENSP00000304139 | CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) | RNA binding motif protein, X-linked-like 2 | 0.412 |
CASKIN1 | SPATA20 | ENSP00000345436 | ENSP00000006658 | CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.648 |
CASKIN1 | WDR63 | ENSP00000345436 | ENSP00000294664 | CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) | WD repeat domain 63 | 0.660 |
PAWR | SPATA20 | ENSP00000328088 | ENSP00000006658 | PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by [...] | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.471 |
RBMXL2 | CASKIN1 | ENSP00000304139 | ENSP00000345436 | RNA binding motif protein, X-linked-like 2 | CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) | 0.412 |
RBMXL2 | SPATA20 | ENSP00000304139 | ENSP00000006658 | RNA binding motif protein, X-linked-like 2 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.521 |
SAT1 | SPATA20 | ENSP00000368572 | ENSP00000006658 | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.450 |
SATL1 | CAPZA1 | ENSP00000425421 | ENSP00000263168 | spermidine/spermine N1-acetyl transferase-like 1 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.405 |
SATL1 | SPATA20 | ENSP00000425421 | ENSP00000006658 | spermidine/spermine N1-acetyl transferase-like 1 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | 0.450 |
SPATA20 | CAPZA1 | ENSP00000006658 | ENSP00000263168 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.512 |
SPATA20 | CAPZA2 | ENSP00000006658 | ENSP00000354947 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.463 |
SPATA20 | CASKIN1 | ENSP00000006658 | ENSP00000345436 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) | 0.648 |
SPATA20 | PAWR | ENSP00000006658 | ENSP00000328088 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by [...] | 0.471 |
SPATA20 | RBMXL2 | ENSP00000006658 | ENSP00000304139 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) | RNA binding motif protein, X-linked-like 2 | 0.521 |