TSR3 protein (Homo sapiens) - STRING network view

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TSR3

TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity) (312 aa)

Predicted Functional Partners:

TSR2

0.923

TSR1

0.865

UBC

0.795

POFUT2

0.761

WDR3

0.599

TBL3

0.584

COX16

0.584

LRP2

0.568

PWP2

0.566

PDCD2

0.539

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX16	TSR3	ENSP00000374562	ENSP00000007390	COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.584
LRP2	TSR3	ENSP00000263816	ENSP00000007390	low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.568
PDCD2	TSR3	ENSP00000439467	ENSP00000007390	programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.539
PDCD2	UBC	ENSP00000439467	ENSP00000344818	programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation	ubiquitin C	0.783
POFUT2	TSR2	ENSP00000339613	ENSP00000364293	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae); May be involved in 20S pre-rRNA processing (Potential)	0.450
POFUT2	TSR3	ENSP00000339613	ENSP00000007390	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.761
PWP2	TBL3	ENSP00000291576	ENSP00000454836	PWP2 periodic tryptophan protein homolog (yeast)	transducin (beta)-like 3	0.997
PWP2	TSR1	ENSP00000291576	ENSP00000301364	PWP2 periodic tryptophan protein homolog (yeast)	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.965
PWP2	TSR2	ENSP00000291576	ENSP00000364293	PWP2 periodic tryptophan protein homolog (yeast)	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae); May be involved in 20S pre-rRNA processing (Potential)	0.456
PWP2	TSR3	ENSP00000291576	ENSP00000007390	PWP2 periodic tryptophan protein homolog (yeast)	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.566
PWP2	UBC	ENSP00000291576	ENSP00000344818	PWP2 periodic tryptophan protein homolog (yeast)	ubiquitin C	0.914
PWP2	WDR3	ENSP00000291576	ENSP00000308179	PWP2 periodic tryptophan protein homolog (yeast)	WD repeat domain 3	0.997
TBL3	PWP2	ENSP00000454836	ENSP00000291576	transducin (beta)-like 3	PWP2 periodic tryptophan protein homolog (yeast)	0.997
TBL3	TSR1	ENSP00000454836	ENSP00000301364	transducin (beta)-like 3	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.929
TBL3	TSR3	ENSP00000454836	ENSP00000007390	transducin (beta)-like 3	TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)	0.584
TBL3	UBC	ENSP00000454836	ENSP00000344818	transducin (beta)-like 3	ubiquitin C	0.898
TBL3	WDR3	ENSP00000454836	ENSP00000308179	transducin (beta)-like 3	WD repeat domain 3	0.998
TSR1	PWP2	ENSP00000301364	ENSP00000291576	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	PWP2 periodic tryptophan protein homolog (yeast)	0.965
TSR1	TBL3	ENSP00000301364	ENSP00000454836	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	transducin (beta)-like 3	0.929
TSR1	TSR2	ENSP00000301364	ENSP00000364293	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae); May be involved in 20S pre-rRNA processing (Potential)	0.951

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