node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP1S2 | CD74 | ENSP00000328789 | ENSP00000009530 | adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.903 |
AP1S2 | HLA-DRB1 | ENSP00000328789 | ENSP00000353099 | adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | major histocompatibility complex, class II, DR beta 1 | 0.900 |
AP1S2 | HLA-DRB5 | ENSP00000328789 | ENSP00000364114 | adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | major histocompatibility complex, class II, DR beta 5 | 0.900 |
AP1S2 | LGMN | ENSP00000328789 | ENSP00000334052 | adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system | 0.905 |
CANX | CD74 | ENSP00000247461 | ENSP00000009530 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.907 |
CANX | CTSD | ENSP00000247461 | ENSP00000236671 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | 0.447 |
CANX | HLA-DRB1 | ENSP00000247461 | ENSP00000353099 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | major histocompatibility complex, class II, DR beta 1 | 0.900 |
CANX | HLA-DRB5 | ENSP00000247461 | ENSP00000364114 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | major histocompatibility complex, class II, DR beta 5 | 0.900 |
CD74 | AP1S2 | ENSP00000009530 | ENSP00000328789 | CD74 molecule, major histocompatibility complex, class II invariant chain | adaptor-related protein complex 1, sigma 2 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.903 |
CD74 | CANX | ENSP00000009530 | ENSP00000247461 | CD74 molecule, major histocompatibility complex, class II invariant chain | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.907 |
CD74 | CTSD | ENSP00000009530 | ENSP00000236671 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | 0.912 |
CD74 | CTSF | ENSP00000009530 | ENSP00000310832 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.960 |
CD74 | CTSL1 | ENSP00000009530 | ENSP00000345344 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.996 |
CD74 | CTSS | ENSP00000009530 | ENSP00000357981 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.988 |
CD74 | HLA-DRB1 | ENSP00000009530 | ENSP00000353099 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 1 | 0.915 |
CD74 | HLA-DRB5 | ENSP00000009530 | ENSP00000364114 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 5 | 0.921 |
CD74 | LGMN | ENSP00000009530 | ENSP00000334052 | CD74 molecule, major histocompatibility complex, class II invariant chain | legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system | 0.915 |
CD74 | MIF | ENSP00000009530 | ENSP00000215754 | CD74 molecule, major histocompatibility complex, class II invariant chain | macrophage migration inhibitory factor (glycosylation-inhibiting factor); Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is impor [...] | 0.977 |
CTSD | CANX | ENSP00000236671 | ENSP00000247461 | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.447 |
CTSD | CD74 | ENSP00000236671 | ENSP00000009530 | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.912 |