FAM76A protein (Homo sapiens) - STRING network view

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FAM76A

family with sequence similarity 76, member A (341 aa)

Predicted Functional Partners:

ATXN1L

0.552

ATXN1

0.552

KIAA0556

0.485

KIAA1429

0.483

ISM1

0.473

LSMD1

0.472

ISM2

0.418

DBP

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1	ATXN1L	ENSP00000244769	ENSP00000415822	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	0.707
ATXN1	FAM76A	ENSP00000244769	ENSP00000010299	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	family with sequence similarity 76, member A	0.552
ATXN1	KIAA0556	ENSP00000244769	ENSP00000261588	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	KIAA0556	0.485
ATXN1L	ATXN1	ENSP00000415822	ENSP00000244769	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	0.707
ATXN1L	FAM76A	ENSP00000415822	ENSP00000010299	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	family with sequence similarity 76, member A	0.552
ATXN1L	KIAA0556	ENSP00000415822	ENSP00000261588	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	KIAA0556	0.485
DBP	FAM76A	ENSP00000222122	ENSP00000010299	D site of albumin promoter (albumin D-box) binding protein; This transcriptional activator recognizes and binds to the sequence 5’-RTTAYGTAAY-3’ found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation	family with sequence similarity 76, member A	0.418
FAM76A	ATXN1	ENSP00000010299	ENSP00000244769	family with sequence similarity 76, member A	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	0.552
FAM76A	ATXN1L	ENSP00000010299	ENSP00000415822	family with sequence similarity 76, member A	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	0.552
FAM76A	DBP	ENSP00000010299	ENSP00000222122	family with sequence similarity 76, member A	D site of albumin promoter (albumin D-box) binding protein; This transcriptional activator recognizes and binds to the sequence 5’-RTTAYGTAAY-3’ found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation	0.418
FAM76A	ISM1	ENSP00000010299	ENSP00000262487	family with sequence similarity 76, member A	isthmin 1 homolog (zebrafish)	0.473
FAM76A	ISM2	ENSP00000010299	ENSP00000341490	family with sequence similarity 76, member A	isthmin 2 homolog (zebrafish)	0.418
FAM76A	KIAA0556	ENSP00000010299	ENSP00000261588	family with sequence similarity 76, member A	KIAA0556	0.485
FAM76A	KIAA1429	ENSP00000010299	ENSP00000297591	family with sequence similarity 76, member A	KIAA1429	0.483
FAM76A	LSMD1	ENSP00000010299	ENSP00000332103	family with sequence similarity 76, member A	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	0.472
ISM1	FAM76A	ENSP00000262487	ENSP00000010299	isthmin 1 homolog (zebrafish)	family with sequence similarity 76, member A	0.473
ISM2	FAM76A	ENSP00000341490	ENSP00000010299	isthmin 2 homolog (zebrafish)	family with sequence similarity 76, member A	0.418
KIAA0556	ATXN1	ENSP00000261588	ENSP00000244769	KIAA0556	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	0.485
KIAA0556	ATXN1L	ENSP00000261588	ENSP00000415822	KIAA0556	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	0.485
KIAA0556	FAM76A	ENSP00000261588	ENSP00000010299	KIAA0556	family with sequence similarity 76, member A	0.485

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