node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR5 | CD38 | ENSP00000292303 | ENSP00000226279 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | 0.514 |
CCR5 | CD4 | ENSP00000292303 | ENSP00000011653 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.991 |
CCR5 | CD69 | ENSP00000292303 | ENSP00000228434 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | CD69 molecule; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets | 0.539 |
CCR5 | CD8A | ENSP00000292303 | ENSP00000283635 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.812 |
CCR5 | FOXP3 | ENSP00000292303 | ENSP00000365380 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.507 |
CCR5 | ITIH4 | ENSP00000292303 | ENSP00000266041 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | 0.978 |
CCR5 | LCK | ENSP00000292303 | ENSP00000337825 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | lymphocyte-specific protein tyrosine kinase | 0.694 |
CCR5 | PTPRC | ENSP00000292303 | ENSP00000356346 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | protein tyrosine phosphatase, receptor type, C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) | 0.526 |
CD2 | CD38 | ENSP00000358490 | ENSP00000226279 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | 0.725 |
CD2 | CD4 | ENSP00000358490 | ENSP00000011653 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.956 |
CD2 | CD69 | ENSP00000358490 | ENSP00000228434 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD69 molecule; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets | 0.513 |
CD2 | CD8A | ENSP00000358490 | ENSP00000283635 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.875 |
CD2 | IL2RA | ENSP00000358490 | ENSP00000369293 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.531 |
CD2 | LCK | ENSP00000358490 | ENSP00000337825 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | lymphocyte-specific protein tyrosine kinase | 0.979 |
CD2 | PTPRC | ENSP00000358490 | ENSP00000356346 | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | protein tyrosine phosphatase, receptor type, C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) | 0.770 |
CD38 | CCR5 | ENSP00000226279 | ENSP00000292303 | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.514 |
CD38 | CD2 | ENSP00000226279 | ENSP00000358490 | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | CD2 molecule; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function | 0.725 |
CD38 | CD4 | ENSP00000226279 | ENSP00000011653 | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.983 |
CD38 | CD69 | ENSP00000226279 | ENSP00000228434 | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | CD69 molecule; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets | 0.564 |
CD38 | CD8A | ENSP00000226279 | ENSP00000283635 | CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.960 |