node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAB39L | MAP4K5 | ENSP00000261669 | ENSP00000013125 | calcium binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity) | mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway | 0.681 |
CRK | CRKL | ENSP00000300574 | ENSP00000346300 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.957 |
CRK | GRB2 | ENSP00000300574 | ENSP00000339007 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.979 |
CRK | MAP3K1 | ENSP00000300574 | ENSP00000382423 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.906 |
CRK | MAP3K7 | ENSP00000300574 | ENSP00000358335 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | mitogen-activated protein kinase kinase kinase 7 | 0.903 |
CRK | MAP4K5 | ENSP00000300574 | ENSP00000013125 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway | 0.977 |
CRKL | CRK | ENSP00000346300 | ENSP00000300574 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | 0.957 |
CRKL | GRB2 | ENSP00000346300 | ENSP00000339007 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.965 |
CRKL | MAP3K1 | ENSP00000346300 | ENSP00000382423 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.901 |
CRKL | MAP3K7 | ENSP00000346300 | ENSP00000358335 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | mitogen-activated protein kinase kinase kinase 7 | 0.903 |
CRKL | MAP4K5 | ENSP00000346300 | ENSP00000013125 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway | 0.971 |
GRB2 | CRK | ENSP00000339007 | ENSP00000300574 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | 0.979 |
GRB2 | CRKL | ENSP00000339007 | ENSP00000346300 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.965 |
GRB2 | MAP3K1 | ENSP00000339007 | ENSP00000382423 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.631 |
GRB2 | MAP4K5 | ENSP00000339007 | ENSP00000013125 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway | 0.863 |
GRB2 | TNFRSF1A | ENSP00000339007 | ENSP00000162749 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase | 0.831 |
MAP3K1 | CRK | ENSP00000382423 | ENSP00000300574 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | 0.906 |
MAP3K1 | CRKL | ENSP00000382423 | ENSP00000346300 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.901 |
MAP3K1 | GRB2 | ENSP00000382423 | ENSP00000339007 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.631 |
MAP3K1 | MAP3K7 | ENSP00000382423 | ENSP00000358335 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | mitogen-activated protein kinase kinase kinase 7 | 0.918 |