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SYT1 SYT1 KCNK1 KCNK1 PSD PSD RAB11FIP2 RAB11FIP2 RAB11FIP5 RAB11FIP5 UBC UBC GNAQ GNAQ ARF6 ARF6 RAB11FIP1 RAB11FIP1 RAB11A RAB11A ARF1 ARF1
"PSD" - pleckstrin and Sec7 domain containing in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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PSDpleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) (1024 aa)    
Predicted Functional Partners:
ARF6
ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension (175 aa)
        score_image   score_image   0.912
KCNK1
potassium channel, subfamily K, member 1; Weakly inward rectifying potassium channel (336 aa)
        score_image   score_image   0.892
RAB11FIP5
RAB11 family interacting protein 5 (class I); Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane (653 aa)
            score_image   0.749
RAB11FIP2
RAB11 family interacting protein 2 (class I); A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity (512 aa)
            score_image   0.747
RAB11FIP1
RAB11 family interacting protein 1 (class I); A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis (1283 aa)
            score_image   0.746
ARF1
ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] (181 aa)
        score_image   score_image   0.627
RAB11A
RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] (216 aa)
        score_image   score_image   0.624
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.621
SYT1
synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
            score_image   0.607
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) (359 aa)
        score_image       0.570
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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